Endoscopic detection of early malignancies in the upper gastrointestinal tract using laser-induced fluorescence imaging

Uwe Sukowski; Bernd Ebert; Marianne Ortner; Katharina Zumbusch; Karsten Mueller; Barbara Fleige; Herbert Lochs; Herbert H. Rinneberg

doi:10.1117/12.413710

31 January 2001 Endoscopic detection of early malignancies in the upper gastrointestinal tract using laser-induced fluorescence imaging

Uwe Sukowski, Bernd Ebert, Marianne Ortner, Katharina Zumbusch, Karsten Mueller, Barbara Fleige, Herbert Lochs, Herbert H. Rinneberg

Author Affiliations +

Proceedings Volume 4156, Clinical Lasers and Diagnostics; (2001) https://doi.org/10.1117/12.413710
Event: EOS/SPIE European Biomedical Optics Week, 2000, Amsterdam, Netherlands

Abstract

Fluorescence images were recorded simultaneously with white light images to detect dyspasia or early malignancies during regular endoscopy of the upper gastrointestinal tract, after topical administration of 5-aminolaevulinic acid. Biopsies were taken at locations where fluorescence intensity were high compared with the mean fluorescence intensity of the image. Prompt and delayed fluorescence spectra of biopsies were subsequently recorded ex vivo, and normalized fluorescence intensities of Protoporphyrin IX derived from these spectra were compared with routine histology. In contrast to routine endoscopy, one early carcinoma and one signet-ring carcinoma were found in the stomach, and malignancies in a duodenal polyp. In addition, intestinal metaplasia could be visualized in the stomach of two patients, which had not been detected in biopsies taken prior to fluorescence endoscopy.

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Uwe Sukowski, Bernd Ebert, Marianne Ortner, Katharina Zumbusch, Karsten Mueller, Barbara Fleige, Herbert Lochs, and Herbert H. Rinneberg "Endoscopic detection of early malignancies in the upper gastrointestinal tract using laser-induced fluorescence imaging", Proc. SPIE 4156, Clinical Lasers and Diagnostics, (31 January 2001); https://doi.org/10.1117/12.413710

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