Mach-Zehnder-type evanescent wave biosensor in ion-exchanged glass using periodically segmented waveguide

Zeev Weissman; E. Brand; I. Tsimberov; David Brooks; Shlomo Ruschin; Doron Goldberg

doi:10.1117/12.346721

21 April 1999 Mach-Zehnder-type evanescent wave biosensor in ion-exchanged glass using periodically segmented waveguide

Zeev Weissman, E. Brand, I. Tsimberov, David Brooks, Shlomo Ruschin, Doron Goldberg

Proceedings Volume 3596, Specialty Fiber Optics for Medical Applications; (1999) https://doi.org/10.1117/12.346721
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Integratred optical Mach-Zehnder interferometric bio-sensors have been implemented in planar glass, by using ion-exchange waveguides. To simplify the fabrication of the sensors, periodically segmented waveguide has been used as the sensing arm, thus avoiding the need to open a sensing window over this arm. To evaluate the device performance, we performed two types of measurements. First, we measured the glucose concentration in a solution. The resulting sensitivity was less than 1 g/l, corresponding to less than 10^-4 in the cover index, for a sensor with a 1 cm long sensing arm, having a segmentation duty-cycle of (eta) equals 0.5. Second, we measured the thickness sensitivity, with respect to the adsorption of avidin molecules onto the glass substrate. The resulting thickness resolution was about 1 Angstrom. Considering that the avidin concentration in the buffer solution was 2.5 (mu) g/mL, that the full thickness of the avidin layer was 2.5 nm, and that the layer buildup time was 7 min., the corresponding sensitivity for the avidin sensor is about 0.25 nM/hr.

Citation Download Citation

Zeev Weissman, E. Brand, I. Tsimberov, David Brooks, Shlomo Ruschin, and Doron Goldberg "Mach-Zehnder-type evanescent wave biosensor in ion-exchanged glass using periodically segmented waveguide", Proc. SPIE 3596, Specialty Fiber Optics for Medical Applications, (21 April 1999); https://doi.org/10.1117/12.346721

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