CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 3592 > Article
Open Access Paper
6 July 1999 Effects of photodynamic therapy on human glioma spheroids
Steen J. Madsen, Chung-Ho Sun, Eugene A. Chu, Henry Hirschberg, Bruce J. Tromberg
Author Affiliations +
Proceedings Volume 3592, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VIII; (1999) https://doi.org/10.1117/12.351505
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States
Abstract
The poor prognosis for patients with malignant brain neoplasm has led to a search for better treatment modalities. Although gliomas are considered to be disseminated tumors in the brain, most recur at the site of the previous tumor resection. Improved local control would thus be of clear benefit. The utility of photodynamic therapy (PDT) in the treatment of brain neoplasms is investigated using a human glioma spheroid model. Specifically, the effects of PDT on human glioma spheroids are investigated using PhotofrinTM and 56-aminolevulinic acid (ALA). The effects of various irradiation schemes were monitored using a simple growth assay. A growth delay was observed at an optical fluence of approximately 35 J cm-2 for spheroids incubated in Photofrin. Spheroids incubated in ALA were unaffected by the PDT treatment regimens examined in this study. This was most likely a result of inadequate photosensitizer concentration.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Steen J. Madsen, Chung-Ho Sun, Eugene A. Chu, Henry Hirschberg, and Bruce J. Tromberg "Effects of photodynamic therapy on human glioma spheroids", Proc. SPIE 3592, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VIII, (6 July 1999); https://doi.org/10.1117/12.351505
PROCEEDINGS
 8 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 2 scholarly publications.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Photodynamic therapy
Tumors
Brain
Ionizing radiation
Luminescence
Plasma
Tissue optics
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top