Copper steam laser irradiation modulates the theraupeutic effect of 5-fluorouracil and the activity of antioxidant enzymes in tumor-bearing mice

N. V. Cherdyntseva; A. Kuznetsova; I. Kondakova; V. Yevtushenko

doi:10.1117/12.311955

29 June 1998 Copper steam laser irradiation modulates the theraupeutic effect of 5-fluorouracil and the activity of antioxidant enzymes in tumor-bearing mice

N. V. Cherdyntseva, A. Kuznetsova, I. Kondakova, V. Yevtushenko

Author Affiliations +

Proceedings Volume 3403, International Conference on Atomic and Molecular Pulsed Lasers II; (1998) https://doi.org/10.1117/12.311955
Event: International Conference on Atomic and Molecular Pulsed Lasers, 1997, Tomsk, Russian Federation

Abstract

Low-energy laser irradiation (LELI) is known to modulate some parameters of immune system and free radical and antioxidant reactions in organism. LELI have been shown to enhance the efficacy of chemo- and radiotherapy in experimental models of tumor growth. The aim of our work was to study the ability of copper steam laser irradiation to modulate the antitumor effect of 5-fluorouracil (5-FU) and antioxidant enzyme activities in blood and tumor tissue of mice with transplanted Lewis lung carcinoma. The data obtained show that the copper steam laser irradiation is able to increase the efficacy of treatment with 5-FU. Laser irradiation increase the SOD activity in plasma and in contrary, decreases it in tumor tissue. Laser irradiation effect on the activity of antioxidant enzymes may be considered as one of the mechanisms mediating its ability to increase the efficacy of cytostatic therapy.

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N. V. Cherdyntseva, A. Kuznetsova, I. Kondakova, and V. Yevtushenko "Copper steam laser irradiation modulates the theraupeutic effect of 5-fluorouracil and the activity of antioxidant enzymes in tumor-bearing mice", Proc. SPIE 3403, International Conference on Atomic and Molecular Pulsed Lasers II, (29 June 1998); https://doi.org/10.1117/12.311955

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