Enhanced Doppler ultrasound imaging of interstitial laser therapy in rat mammary tumors

James M. Zasuly M.D.; Ming Fan; Kambiz Dowlatshahi M.D.

doi:10.1117/12.275093

22 May 1997 Enhanced Doppler ultrasound imaging of interstitial laser therapy in rat mammary tumors

James M. Zasuly M.D., Ming Fan, Kambiz Dowlatshahi M.D.

Proceedings Volume 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII; (1997) https://doi.org/10.1117/12.275093
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

In order to better develop ultrasonography for use in monitoring interstitial laser therapy (ILT), we imaged rat mammary tumors using power Doppler ultrasound in conduction with intravenous contrast agent (Albunex) before and after laser therapy. Small vessel perfusion throughout a variable portion of the tumor could be detected by power Doppler ultrasound. Lesions created with diode laser by delivery of 500 to 3000 J appeared as perfusion defects on post-treatment images. Image topography and lesion size correlated with gross histologic findings. We conclude that ultrasonographic monitoring of local changes in blood flow using contrast enhancing agent can be useful in characterizing lesions created with ILT.

Citation Download Citation

James M. Zasuly M.D., Ming Fan, and Kambiz Dowlatshahi M.D. "Enhanced Doppler ultrasound imaging of interstitial laser therapy in rat mammary tumors", Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); https://doi.org/10.1117/12.275093

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