Investigating the potential molecular mechanisms of Salvia miltiorrhiza Burge in the treatment of long COVID: a bioinformatics approach

Yiwei Fu; Zhengli Yu

doi:10.1117/12.3044471

27 August 2024 Investigating the potential molecular mechanisms of Salvia miltiorrhiza Burge in the treatment of long COVID: a bioinformatics approach

Yiwei Fu, Zhengli Yu

Author Affiliations +

Proceedings Volume 13252, Fourth International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2024); 132521S (2024) https://doi.org/10.1117/12.3044471
Event: 2024 Fourth International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2024), 2024, Kaifeng, China

Abstract

Long-term neocoronitis remains a complex and not fully understood medical condition, manifesting with persistent symptoms such as fatigue, cognitive problems and joint discomfort long after the acute phase of neocoronitis has passed. Salvia miltiorrhiza is an important element of Chinese medicine that has shown promise in alleviating these persistent symptoms. However, the biochemical pathways by which it exerts its therapeutic effects have not been clearly defined. In this study, we investigated the possible molecular pathways by which danshen alleviates prolonged coronavirus symptoms using computational biology techniques. We analyzed the protein targets activated by metabolites formed after salvia ingestion and identified potential therapeutic targets for prolonged coronavirus COVID. By constructing a protein-protein interaction network, performing gene ontology, and enrichment analysis of cross genes by Kyoto Gene and Genome Encyclopedia, we identified key targets and biological pathways. This study reveals the underlying biochemical mechanisms by which Salvia divinorum exerts its therapeutic effects on long coronaviruses and provides a basis for the development of more targeted therapeutic strategies against this complex disease.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Yiwei Fu and Zhengli Yu "Investigating the potential molecular mechanisms of Salvia miltiorrhiza Burge in the treatment of long COVID: a bioinformatics approach", Proc. SPIE 13252, Fourth International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2024), 132521S (27 August 2024); https://doi.org/10.1117/12.3044471

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KEYWORDS

Proteins

COVID 19

Biological research

Databases

Bioinformatics

Modulation

Signal processing

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