Biosensing applications based on metallic nanostructures

Yifei Gao; Shurui Deng; Lilun Xu; Yanshan Lin; Domna G. Kotsifaki

doi:10.1117/12.3037509

27 November 2024 Biosensing applications based on metallic nanostructures

Yifei Gao, Shurui Deng, Lilun Xu, Yanshan Lin, Domna G. Kotsifaki

Proceedings Volume 13245, Plasmonics VIII; 132450L (2024) https://doi.org/10.1117/12.3037509
Event: SPIE/COS Photonics Asia, 2024, Nantong, Jiangsu, China

Abstract

We designed and fabricated an array of metallic nano-aperture on a gold film to enhance the detection of immunoglobulin G (IgG) protein in the liquid environment. The plasmonic nanostructure is designed to exhibit a resonance at 762 nm. The field enhancement improved the sensitivity of the system, enabling the detection of IgG protein at low concentrations, i.e. 4 ng/ml. Raman spectroscopy was employed to record the protein’s spectral signatures at multiple locations across the plasmonic nanostructure under laser excitation at 530 nm, revealing an enhancement in the Raman signal. This work paves the way for developing plasmonic nanostructures suitable for large-scale applications, with particular potential in diagnostics and environmental studies.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Yifei Gao, Shurui Deng, Lilun Xu, Yanshan Lin, and Domna G. Kotsifaki "Biosensing applications based on metallic nanostructures", Proc. SPIE 13245, Plasmonics VIII, 132450L (27 November 2024); https://doi.org/10.1117/12.3037509

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