Blood coagulation monitoring using refractive index

John Forshay; Luis Trabucco; Jing Yong Ye

doi:10.1117/12.3038856

21 October 2024 Blood coagulation monitoring using refractive index

John Forshay, Luis Trabucco, Jing Yong Ye

Proceedings Volume 13186, SPIE Translational Biophotonics + Additive Manufacturing for Photonics 2024; 131861P (2024) https://doi.org/10.1117/12.3038856
Event: SPIE Translational Biophotonics + Additive Manufacturing for Photonics, 2024, Houston, Texas, United States

Conference Poster

Abstract

Prothrombin, or factor II, is vital in blood coagulation, transforming into active thrombin. The prothrombin time test (PTT) measures blood clotting time, crucial for heart disease patients on anticoagulants. Our study introduces a novel approach using refractive index to measure prothrombin time, validated through experimental outcomes. This method leverages light refraction principles, offering rapid results, simplicity, and point-of-care potential. Testing with clinical samples showed strong correlation with traditional PTT methods. Developing a point-of-care device for prothrombin time measurement promises to enhance patient care by enabling real-time monitoring of clotting efficiency, allowing timely adjustments to anticoagulant therapy, thus reducing risks of bleeding or thrombosis. The simplicity and accessibility of this method can revolutionize anticoagulant management, especially in resource-limited settings.

Citation Download Citation

John Forshay, Luis Trabucco, and Jing Yong Ye "Blood coagulation monitoring using refractive index", Proc. SPIE 13186, SPIE Translational Biophotonics + Additive Manufacturing for Photonics 2024, 131861P (21 October 2024); https://doi.org/10.1117/12.3038856

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available