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29 May 2024 Normalized comparison of cancer detection rates in contemporary breast imaging technologies used in dense-breast supplemental screening
Martin P. Tornai, James W. Hugg, Bradley E. Patt, Chin-Tu Chen, Eduardo A. Santos, Matthew F. Covington
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Proceedings Volume 13174, 17th International Workshop on Breast Imaging (IWBI 2024); 131740E (2024) https://doi.org/10.1117/12.3027029
Event: 17th International Workshop on Breast Imaging (IWBI 2024), 2024, Chicago, IL, United States
Abstract
We present an objective analysis and comparison on a level technological playing field of Cancer Detection Rates (CDRs) by performing a meta-analysis from publications about dense breasts using FDA-approved imaging modalities available for supplemental breast cancer screening in the USA. Awareness is growing about the relatively low overall cancer detection rate of digital mammography (DM), digital breast tomosynthesis (DBT) and breast ultrasound (US), especially for the nearly 25 million screening-eligible women with increased breast density (BIRADS C,D). Since a majority of research papers use comparisons to the screening “gold standard” of DM, analysis using pooled CDRs normalized to DM is presented. Other important factors such as the number of theoretical net lives saved using a benefit-to-risk comparison of ionizing imaging modalities is included. Lingering concerns about ionizing radiation dose of supplemental screening options are also discussed with the comparative perspective of the unavoidable yearly background dose every human being receives. This objective, normalized analysis identifies contrast-enhanced mammography (CEM) and molecular breast imaging (MBI) to have Cancer Detection Rates (CDR) within 90% (and greater) of breast magnetic resonance imaging (MRI). These top-three “vascular imaging modalities” each employ injected contrast agents to enhance visualization and facilitate the detection of early-stage breast cancers. By enabling earlier diagnosis with more appropriate supplemental breast imaging, the use of either CEM, MBI or MRI will: decrease mortality; reduce patient’s physical, financial and psychological trauma; and reduce costs per cancer detected earlier, with overall benefit to the patients, the hospitals and the payors, thus providing long-term societal benefits.
(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
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Martin P. Tornai, James W. Hugg, Bradley E. Patt, Chin-Tu Chen, Eduardo A. Santos, and Matthew F. Covington "Normalized comparison of cancer detection rates in contemporary breast imaging technologies used in dense-breast supplemental screening", Proc. SPIE 13174, 17th International Workshop on Breast Imaging (IWBI 2024), 131740E (29 May 2024); https://doi.org/10.1117/12.3027029
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KEYWORDS
Breast
Digital breast tomosynthesis
Breast imaging
Cancer detection
Breast cancer
Magnetic resonance imaging
Cancer
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