Full-field multimodal imaging technology of x-ray transmission, fluorescence, and scattering tomography (PI-CT) with polychromatic source

Liang Li; Jiadan Song; Shaozhou Pu

doi:10.1117/12.3027432

23 October 2024 Full-field multimodal imaging technology of x-ray transmission, fluorescence, and scattering tomography (PI-CT) with polychromatic source

Liang Li, Jiadan Song, Shaozhou Pu

Author Affiliations +

Proceedings Volume 13152, Developments in X-Ray Tomography XV; 131521A (2024) https://doi.org/10.1117/12.3027432
Event: Optical Engineering + Applications, 2024, San Diego, California, United States

Abstract

This paper introduces and discusses the development of an interesting multimodal CT imaging technique, called full x-ray particle information CT (PI-CT), which combines x-ray transmission, fluorescence, and scattering tomography using a polychromatic x-ray source. The PI-CT allows for the simultaneous reconstruction of high-resolution tissue structure images, quantitative imaging of high-Z element concentrations, and electron density distributions. During x-ray photons passing through an object, photoelectric effects and Compton scattering may occur, resulting in x-ray attenuation and the generation of scattering and fluorescent photons. All these interaction information is innovatively utilized in PI-CT to detect and image different physical quantities inside the object. X-ray transmission CT could image the object’s high-resolution structure. X-ray fluorescence CT could realize the quantitative imaging of high-Z agents. Compton scattering CT could reconstruct the electron density information, which may have better contrast in weak absorption radiation imaging cases, such as lung imaging. Therefore, with the help of functional imaging nanoparticles, PI-CT can provide both high-resolution tissue structure images and highly sensitive molecular functional images of living animals, which provides a new multimodal tool for tumor diagnosis and treatment. Experimental results demonstrate the potential of PI-CT in enhancing multimodal CT imaging, particularly in tumor diagnosis and treatment applications.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Liang Li, Jiadan Song, and Shaozhou Pu "Full-field multimodal imaging technology of x-ray transmission, fluorescence, and scattering tomography (PI-CT) with polychromatic source", Proc. SPIE 13152, Developments in X-Ray Tomography XV, 131521A (23 October 2024); https://doi.org/10.1117/12.3027432

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