Wireless, battery-free, fully implantable optoelectronic devices and systems for tissue oxygen sensing

He Ding; Zhao Xue; Xue Cai; Xing Sheng

doi:10.1117/12.3017317

20 June 2024 Wireless, battery-free, fully implantable optoelectronic devices and systems for tissue oxygen sensing

He Ding, Zhao Xue, Xue Cai, Xing Sheng

Author Affiliations +

Proceedings Volume 13007, Neurophotonics II; 1300704 (2024) https://doi.org/10.1117/12.3017317
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Real-time monitoring of tissue oxygenation within the nervous system is imperative for advancements in neuroscience research and the improvement of clinical diagnostics. Unlike blood oxygenation levels, the partial pressure of oxygen in brain tissue (PbtO₂) offers a more direct insight into the localized neural activities and metabolic states. Here, we present a microscale optoelectronic probe for the wireless, real-time monitoring of in vivo partial brain tissue oxygen (PbtO₂) levels. This probe measures local PbtO₂ concentrations via the luminescent quenching mechanism of phosphorescent dyes. An integrated light-emitting diode (LED) and photodetector are used to generate and capture the optical signals. To facilitate capturing and wirelessly transmitting PbtO₂ signals, the device includes miniaturized electronic circuits that can be powered by a battery or an inductive coil. In vitro and in vivo experiments demonstrate the ability to dynamically record oxygen partial pressure (pO₂), offering novel exploration opportunities in neuroscience research and clinical applications.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

He Ding, Zhao Xue, Xue Cai, and Xing Sheng "Wireless, battery-free, fully implantable optoelectronic devices and systems for tissue oxygen sensing", Proc. SPIE 13007, Neurophotonics II, 1300704 (20 June 2024); https://doi.org/10.1117/12.3017317

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