Noninvasive glucose sensing with detecting the optical rotation of glucose in the aqueous humor

Yujiro Yanai; Fumitake Mitobe; Yukito Saitoh; Michio Nagai; Yoji Ito

doi:10.1117/12.3002015

12 March 2024 Noninvasive glucose sensing with detecting the optical rotation of glucose in the aqueous humor

Yujiro Yanai, Fumitake Mitobe, Yukito Saitoh, Michio Nagai, Yoji Ito

Proceedings Volume 12845, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2024; 1284506 (2024) https://doi.org/10.1117/12.3002015
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We have developed a new method to detect the optical rotation of glucose in the aqueous humor with high accuracy, separating the influence of the cornea with a phase difference thousands of times larger than that of glucose. Using this method and a simple experimental system simulating the eye (cornea and aqueous humor), we confirmed the detection of optical rotation of glucose at a normal glucose concentration equivalent (approximately 100 (mg/dl)) to aqueous glucose solution. We believe that this result will significantly advance the development of painless noninvasive glucose sensors.

Conference Presentation

Citation Download Citation

Yujiro Yanai, Fumitake Mitobe, Yukito Saitoh, Michio Nagai, and Yoji Ito "Noninvasive glucose sensing with detecting the optical rotation of glucose in the aqueous humor", Proc. SPIE 12845, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2024, 1284506 (12 March 2024); https://doi.org/10.1117/12.3002015

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