A microfluidic-based cerebral perfusion phantom for laser speckle imaging in small animals

Susweta Das; Ria Paul; Soumyajit Sarkar; Makrand Rakshe; Prasanna Gandhi; Hari M. Varma

doi:10.1117/12.2670972

9 August 2023 A microfluidic-based cerebral perfusion phantom for laser speckle imaging in small animals

Susweta Das, Ria Paul, Soumyajit Sarkar, Makrand Rakshe, Prasanna Gandhi, Hari M. Varma

Proceedings Volume 12628, Diffuse Optical Spectroscopy and Imaging IX; 126281B (2023) https://doi.org/10.1117/12.2670972
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

We introduce a novel cerebral perfusion phantom to calibrate laser speckle imaging systems for small animal brain imaging. A method based on Hele-Shaw cell technique is used to create fractal like structures which serves as the mould for the phantom making. The structure is casted to create micro channels in PDMS phantoms which is found to closely mimic the structure of superficial cerebral blood vessels in small animals. The proposed method has the potential to fabricate optically and anatomically accurate cerebral perfusion phantom using a quick and inexpensive fabrication technique suitable for blood flow imaging studies.

Citation Download Citation

Susweta Das, Ria Paul, Soumyajit Sarkar, Makrand Rakshe, Prasanna Gandhi, and Hari M. Varma "A microfluidic-based cerebral perfusion phantom for laser speckle imaging in small animals", Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX, 126281B (9 August 2023); https://doi.org/10.1117/12.2670972

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