Neuroinflammation as a core pathogenic mechanism of Alzheimer’s disease: recent research advances and related therapeutical approaches

Zongzheng Xue

doi:10.1117/12.2669000

24 March 2023 Neuroinflammation as a core pathogenic mechanism of Alzheimer’s disease: recent research advances and related therapeutical approaches

Zongzheng Xue

Author Affiliations +

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126111N (2023) https://doi.org/10.1117/12.2669000
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ) accumulation, tau deposition, oxidative stress, and neuroinflammation. However, recent research focused more on neuroinflammation and oxidative stress than protein deposits, as the therapeutical effect against the latter has been relatively disappointing over the years. Since then, many novel findings have emerged, indicating neuroinflammation as another crucial contributor in AD pathogenesis rather than a secondary effect of protein deposition, and shed some light on the therapeutical design for AD. This paper will discuss some new understanding of neuroinflammation in AD. Unlike what is previously known as an immune-privileged site, the brain has a solid immune response upon detecting foreign pathogens and protein deposits, mediated mainly by glial cells. This immune response then ends with chronic neuroinflammation, which accelerates AD progression. Thus, this paper will highlight the role of glial cells in neuroinflammation and bring up the usually neglected contribution of periphery immune system and microbiomes infection as well, together depict a broader picture of neuroinflammation in the pathogenesis of AD, along with potential therapeutical advance with an emphasis on immunotherapy.

Citation Download Citation

Zongzheng Xue "Neuroinflammation as a core pathogenic mechanism of Alzheimer’s disease: recent research advances and related therapeutical approaches", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126111N (24 March 2023); https://doi.org/10.1117/12.2669000

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available