Synthesis of rare Earth fluorescent probe intermediates by homogeneous time-resolved fluorescence immunoassay

Shengnan Zhao; Shuangshuang Zhao; Qingxin Zhao; Yan Guo

doi:10.1117/12.2668609

14 February 2023 Synthesis of rare Earth fluorescent probe intermediates by homogeneous time-resolved fluorescence immunoassay

Shengnan Zhao, Shuangshuang Zhao, Qingxin Zhao, Yan Guo

Author Affiliations +

Proceedings Volume 12589, International Conference on Optical Technology, Semiconductor Materials, and Devices (OTSMD 2022); 125890F (2023) https://doi.org/10.1117/12.2668609
Event: International Conference on Optical Technology, Semiconductor Materials, and Devices (OTSMD 2022), 2022, Longyan, China

Abstract

In order to prepare a novel cave-like bifunctional chelating agent for homogeneous phase time-resolved fluorescence immunoassay, using 2-benzyl oxo carbonyl 6-tert-butyl oxo carbonyl. The intermediate, 5-amino-(2-aminoethyl)-H(2,2)- aminotert-butyl ester E-14, was synthesized by five steps of reduction, oxidation, amination and hydrogenation of -L-lysine E-7. The synthesis methods and conditions of the first steps were mainly studied, and the molecular structure was analyzed by means of Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared Spectrometer (FTIR), Mass Spectrometry (MS). It provides a valuable intermediate and preparation method for the application of homogeneous time resolved fluorescence immunoassay.

Citation Download Citation

Shengnan Zhao, Shuangshuang Zhao, Qingxin Zhao, and Yan Guo "Synthesis of rare Earth fluorescent probe intermediates by homogeneous time-resolved fluorescence immunoassay", Proc. SPIE 12589, International Conference on Optical Technology, Semiconductor Materials, and Devices (OTSMD 2022), 125890F (14 February 2023); https://doi.org/10.1117/12.2668609

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