Multifocal optical metasurfaces for cellular-resolution optical coherence tomography for rapid slide-free histology of human brain and skin samples

Jingjing Zhao; Aidan Van Vleck; Yonatan Winetraub; Lin Du; Yong Han; Sumaira Aasi; Kavita Yang Sarin; Adam de la Zerda

doi:10.1117/12.2654983

7 April 2023 Multifocal optical metasurfaces for cellular-resolution optical coherence tomography for rapid slide-free histology of human brain and skin samples

Jingjing Zhao, Aidan Van Vleck, Yonatan Winetraub, Lin Du, Yong Han, Sumaira Aasi, Kavita Yang Sarin, Adam de la Zerda

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Proceedings Volume 12471, Medical Imaging 2023: Digital and Computational Pathology; 124711U (2023) https://doi.org/10.1117/12.2654983
Event: SPIE Medical Imaging, 2023, San Diego, California, United States

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Abstract

Cellular resolution of optical coherence tomography (OCT) is vital to achieving precise diagnosis by offering high-quality images of slide-free histology. Currently, the common solution is to apply dynamic focusing to axially translate the focus through the region of interest with a high numerical aperture (N.A.) objective, followed by Z-stacking to rebuild a high-resolution 3D volume. To accelerate the imaging acquisition, this work developed optical metasurface plates to generate multiple foci along the axial direction. Two-/three-/seven-foci had been testified with bead phantom using a scanning OCT. Human skin and human brain samples were imaged with cellular resolution.

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Jingjing Zhao, Aidan Van Vleck, Yonatan Winetraub, Lin Du, Yong Han, Sumaira Aasi, Kavita Yang Sarin, and Adam de la Zerda "Multifocal optical metasurfaces for cellular-resolution optical coherence tomography for rapid slide-free histology of human brain and skin samples", Proc. SPIE 12471, Medical Imaging 2023: Digital and Computational Pathology, 124711U (7 April 2023); https://doi.org/10.1117/12.2654983

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