Multilayered nanoparticles as optical sensors for amyloid ß-peptide (1-42) targeting in liquid samples

Caterina Dallari; Elena Lenci; Andrea Trabocchi; Valentina Bessi; Silvia Bagnoli; Benedetta Nacmias; Caterina Credi; Francesco Saverio Pavone

doi:10.1117/12.2649834

17 March 2023 Multilayered nanoparticles as optical sensors for amyloid ß-peptide (1-42) targeting in liquid samples

Caterina Dallari, Elena Lenci, Andrea Trabocchi, Valentina Bessi, Silvia Bagnoli, Benedetta Nacmias, Caterina Credi, Francesco Saverio Pavone

Author Affiliations +

Proceedings Volume 12395, Colloidal Nanoparticles for Biomedical Applications XVIII; 123950B (2023) https://doi.org/10.1117/12.2649834
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Alzheimer’s Disease (AD) is a severe neurodegenerative disorder, marked by cognitive decline, memory loss, and behavioral skill impairment. Actually, amyloid β-peptide 1-42 (Aβ (1-42)) is one of the main recognized AD biomarkers. The possibility of detect Aβ (1-42) at very low concentration in different biological fluids allow the early-stage diagnosis, which currently represents the most efficacious AD therapy. To date, optical detection techniques have gained rising attention for the development of Aβ (1-42) sensors based on the analyses of liquid samples. In this context, optical metallic nanoconstructs are promising alternative for the development of novel rapid and low-cost methods for the targeting of Aβ (1-42) in fluids. Herein, diagnostic platforms are based on gold citratecapped nanoparticles (AuNPs), whose aggregation can be modulated by the presence of the target biomarker as a function of its concentration and has been smartly used to develop colorimetric assays. The performances of this novel system are validated for specific detection of synthetic ß- amyloid peptide (Aß) in liquid fluids with high selectivity and sensitivity down to the nanomolar.

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Caterina Dallari, Elena Lenci, Andrea Trabocchi, Valentina Bessi, Silvia Bagnoli, Benedetta Nacmias, Caterina Credi, and Francesco Saverio Pavone "Multilayered nanoparticles as optical sensors for amyloid ß-peptide (1-42) targeting in liquid samples", Proc. SPIE 12395, Colloidal Nanoparticles for Biomedical Applications XVIII, 123950B (17 March 2023); https://doi.org/10.1117/12.2649834

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