Chelation of gadolinium with carbonized citric and folic acids

Ekaterina A. Mordovina; Daria V. Tsyupka; Artem A. Bakal; Anna M. Abramova; Irina Yu. Goryacheva

doi:10.1117/12.2624023

29 April 2022 Chelation of gadolinium with carbonized citric and folic acids

Ekaterina A. Mordovina, Daria V. Tsyupka, Artem A. Bakal, Anna M. Abramova, Irina Yu. Goryacheva

Proceedings Volume 12192, Optical Technologies for Biology and Medicine; 1219206 (2022) https://doi.org/10.1117/12.2624023
Event: XXV Annual Conference Saratov Fall Meeting 2021; and IX Symposium on Optics and Biophotonics, 2021, Saratov, Russian Federation

Abstract

Most radiological methods for examining the body, such as magnetic resonance therapy, radiography, ultrasound diagnostics, and many others demand the use of contrast agents. The existing contrast agents are imperfect and require further improvement. A special place among contrast agents is occupied by specific contrast agents, which allow targeted contrasting through the use of special ligands (for example, folic acid). In this work, we describe the preparation of stable gadolinium chelates with carbon nanostructures, which exhibit bright fluorescence and contain folic acid in their structure, available for binding to receptors. This opens up the possibility of using such structures for targeted contrast enhancement, as well as for local visualization of cancer cells and tissues.

Citation Download Citation

Ekaterina A. Mordovina, Daria V. Tsyupka, Artem A. Bakal, Anna M. Abramova, and Irina Yu. Goryacheva "Chelation of gadolinium with carbonized citric and folic acids", Proc. SPIE 12192, Optical Technologies for Biology and Medicine, 1219206 (29 April 2022); https://doi.org/10.1117/12.2624023

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available