Pathological studies using laserthermia with Nd:YAG laser

Naoto Mamiya; Hiroshi Tsunekawa M.D.; M. Sugihara M.D.; Masataka Shinoda; Yoko Sasano; Chein Chang Chen; Kenji Ina M.D.; Kimitomo Morise M.D.; Yoshinori Watanabe; Tsutomu Tsunekawa; Norio Daikuzono

doi:10.1117/12.17595

1 July 1990 Pathological studies using laserthermia with Nd:YAG laser

Naoto Mamiya, Hiroshi Tsunekawa M.D., M. Sugihara M.D., Masataka Shinoda, Yoko Sasano, Chein Chang Chen, Kenji Ina M.D., Kimitomo Morise M.D., Yoshinori Watanabe, Tsutomu Tsunekawa, Norio Daikuzono

Author Affiliations +

Proceedings Volume 1201, Optical Fibers in Medicine V; (1990) https://doi.org/10.1117/12.17595
Event: OE/LASE '90, 1990, Los Angeles, CA, United States

Abstract

In 198k we developed a method of hyperthermia using Nd:YAG laser (laser thermia) a system for transmitting continuous low power energy (2 W) through an artificial sapphire interstitial probe for local hyperthermia (43-0.5°C). Our experimental and clinical evidence indicated that this method is safe and effective. The process of tumor destruction induced by laser thermia is, however, poorly understood. We performed in vivo histopathological studies and obtained the following results; 1) At the tissue level, the initial change after laser thermia was the damage of tumor feeding vessels. 2) At the cell level, immediately after laser thermia the mitochondria in the intracellular organella were completely destroyed.

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Naoto Mamiya, Hiroshi Tsunekawa M.D., M. Sugihara M.D., Masataka Shinoda, Yoko Sasano, Chein Chang Chen, Kenji Ina M.D., Kimitomo Morise M.D., Yoshinori Watanabe, Tsutomu Tsunekawa, and Norio Daikuzono "Pathological studies using laserthermia with Nd:YAG laser", Proc. SPIE 1201, Optical Fibers in Medicine V, (1 July 1990); https://doi.org/10.1117/12.17595

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