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5 March 2021 Label-free fluorescence lifetime techniques for image-guided surgery
Laura Marcu
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Proceedings Volume 11656, Advanced Chemical Microscopy for Life Science and Translational Medicine 2021; 116560Z (2021) https://doi.org/10.1117/12.2583253
Event: SPIE BiOS, 2021, Online Only
Abstract
This presentation overviews fluorescence lifetime spectroscopy and imaging techniques for label-free in vivo tissue diagnosis. Emphasis is placed on recently developed devices and methods enabling real-time characterization of tissue biochemical makeup during clinical interventions. I will present studies conducted in human patients demonstrating the ability of these techniques to provide a rapid in-situ evaluation of tissue biochemical properties, rapid classification of distinct tissue types, real-time augmentation of the tissue classifier on surgical field of view, and ultimately their potential to guide surgical procedures. Current results demonstrate that intrinsic fluorescence can provide useful contrast for intraoperative delineation of primary brain cancer at the resection margins and oral and oropharyngeal cancer.
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Laura Marcu "Label-free fluorescence lifetime techniques for image-guided surgery", Proc. SPIE 11656, Advanced Chemical Microscopy for Life Science and Translational Medicine 2021, 116560Z (5 March 2021); https://doi.org/10.1117/12.2583253
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KEYWORDS
Luminescence
Image-guided intervention
Tissues
Imaging spectroscopy
Cancer
Fluorescence spectroscopy
In vivo imaging
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