Time-domain reflectance diffuse optical tomography for imaging breast cancer

Kenji Yoshimoto; Hiroko Wada; Nobuko Yoshizawa; Hiroyuki Ogura; Etsuko Ohmae; Hiroaki Suzuki; Shu Homma; Tetsuya Mimura; Norihiro Suzuki; Yuko Asano; Satoshi Goshima; Yukio Ueda

doi:10.1117/12.2576597

9 March 2021 Time-domain reflectance diffuse optical tomography for imaging breast cancer

Kenji Yoshimoto, Hiroko Wada, Nobuko Yoshizawa, Hiroyuki Ogura, Etsuko Ohmae, Hiroaki Suzuki, Shu Homma, Tetsuya Mimura, Norihiro Suzuki, Yuko Asano, Satoshi Goshima, Yukio Ueda

Author Affiliations +

Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 116391I (2021) https://doi.org/10.1117/12.2576597
Event: SPIE BiOS, 2021, Online Only

Conference Poster

Abstract

We report a time-domain reflectance diffuse optical tomography (TD-RDOT) system for providing three-dimensional images of hemoglobin concentration, tissue oxygen saturation, water and lipid contents of breast cancer from reflectance measurements. A scan area of 5 × 5 grid points with a 10-mm spacing is marked on the breast surface so that the tumor is just below the center of the area. The breast scan is performed by measuring the temporal profiles of six wavelengths at each grid point using a time-domain diffuse optical spectroscopy (TD-DOS) system and a hand-held probe. The TDDOS system that we developed is capable of measuring water and lipid contents and hemoglobin concentration. The hand-held probe is designed to measure the breast in reflectance mode with a source-to-detector separation of 20 mm. The three-dimensional distributions of the tissue parameters are restored using an iterative image reconstruction method. As a preliminary clinical demonstration, a breast cancer patient with a tumor size of approximately 20 mm was examined with the TD-RDOT. The reconstructed images show that the breast cancer had high hemoglobin concentration and water content, and low tissue oxygen saturation and lipid content. The results indicate that the TD-RDOT system has the potential to provide diagnostically relevant information on the tissue characteristics of the tumor at the bedside.

Citation Download Citation

Kenji Yoshimoto, Hiroko Wada, Nobuko Yoshizawa, Hiroyuki Ogura, Etsuko Ohmae, Hiroaki Suzuki, Shu Homma, Tetsuya Mimura, Norihiro Suzuki, Yuko Asano, Satoshi Goshima, and Yukio Ueda "Time-domain reflectance diffuse optical tomography for imaging breast cancer", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 116391I (9 March 2021); https://doi.org/10.1117/12.2576597

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available