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5 March 2021 Macrophage specific delivery of photosensitizer and light activation reduce inflammation and burden of atherosclerotic plaque via activation of autophagy and efferocytosis of apoptotic cells
Joon Woo Song, Jae Won Ahn, Min Woo Lee, Hyun Jung Kim, Dong Oh Kang M.D., Ryeong Hyun Kim, Un Gyo Kang, Yeon Hoon Kim, Jeongmoo Han, Hyeong Soo Nam, Hongki Yoo, Kyeongsoon Park, Jin Won Kim
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Proceedings Volume 11621, Diagnostic and Therapeutic Applications of Light in Cardiology 2021; 116210B (2021) https://doi.org/10.1117/12.2579185
Event: SPIE BiOS, 2021, Online Only
Abstract
Photoactivation is a promising theranostic tool to image and stabilize the atherosclerotic plaque by apoptosis induction in macrophages or other vascular cells; however, lack of effective drugs and mechanistic understanding hinder its clinical application for cardiovascular disease. Here, we developed the macrophage targeted photosensitizer delivery strategy and demonstrated that imaging assisted light activation reduced inflammation and burden of atherosclerotic plaques. Mechanistically, targeted photoactivation induced autophagy and increased MerTK expression in carotid atheroma as early as 1 day, and had 2-fold increase in macrophage-associated apoptotic cells, indicating efferocytosis enhancement. This multifunctional photoactivatable theranostic strategy could confer a promising tool for high-risk plaques.
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Joon Woo Song, Jae Won Ahn, Min Woo Lee, Hyun Jung Kim, Dong Oh Kang M.D., Ryeong Hyun Kim, Un Gyo Kang, Yeon Hoon Kim, Jeongmoo Han, Hyeong Soo Nam, Hongki Yoo, Kyeongsoon Park, and Jin Won Kim "Macrophage specific delivery of photosensitizer and light activation reduce inflammation and burden of atherosclerotic plaque via activation of autophagy and efferocytosis of apoptotic cells", Proc. SPIE 11621, Diagnostic and Therapeutic Applications of Light in Cardiology 2021, 116210B (5 March 2021); https://doi.org/10.1117/12.2579185
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KEYWORDS
Inflammation
Laser irradiation
Cell death
In vivo imaging
Receptors
Foam
Luminescence
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