NIKOS II - A System For Non-Invasive Imaging Of Coronary Arteries With Synchrotron Radiation

W.-R. Dix; K. Engelke; J. Heuer; W. Graeff; W. Kupper; M. Lohmann; I. Makin; T. Mochel; R. Reumann

doi:10.1117/12.961738

18 October 1989 NIKOS II - A System For Non-Invasive Imaging Of Coronary Arteries With Synchrotron Radiation

W.-R. Dix, K. Engelke, J. Heuer, W. Graeff, W. Kupper, M. Lohmann, I. Makin, T. Mochel, R. Reumann

Proceedings Volume 1137, Science and Engineering of Medical Imaging; (1989) https://doi.org/10.1117/12.961738
Event: 1989 International Congress on Optical Science and Engineering, 1989, Paris, France

Abstract

Aim of the work is the visualization of coronary arteries down to 1 mm diameter with an iodine mass density of 1 mg/cm , thus allowing non-invasive investigations by intravenous injection of the contrast agent. Digital Subtraction Angiography (DSA) in energy subtraction mode (dichromography) is employed for this purpose. The two images Cor subtraction are taken at photon energies just below and above the iodine K-edge (33.17 keV). After subtraction the background contrast - such as bone and soft tissue - is suppressed and the iodinated structures are strongly enhanced because of the abrupt change of absorption at the edge. The two monoenergetic beams (bandwidth about 250 eV) with high intensity (about 1011 photons/mm /s) are only available if synchrotron radiation is used. In HASYLAB at DESY (Hamburg, FRG) the system NIKOS was developed for dichromography. It consists of six main parts: A wiggler beam line, a monochromator which filters the two 12 cm wide beams out of the white synchrotron radiation beam, a fast scanning device, a fast low-noise two-line detector, a safety system and a computer system. At present, one scan (two images) lasts 1 s. The images from the in-vivo investigations of dogs have been promising. The right coronary artery (diameter 1.5 mm) was clearly visible.

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W.-R. Dix, K. Engelke, J. Heuer, W. Graeff, W. Kupper, M. Lohmann, I. Makin, T. Mochel, and R. Reumann "NIKOS II - A System For Non-Invasive Imaging Of Coronary Arteries With Synchrotron Radiation", Proc. SPIE 1137, Science and Engineering of Medical Imaging, (18 October 1989); https://doi.org/10.1117/12.961738

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