Multifractal analysis of low coherence spectra for oral cancer detection

Gyana Ranjan Sahoo; Dipti Bharti; Asima Pradhan

doi:10.1117/12.2547189

21 February 2020 Multifractal analysis of low coherence spectra for oral cancer detection

Gyana Ranjan Sahoo, Dipti Bharti, Asima Pradhan

Proceedings Volume 11253, Biomedical Applications of Light Scattering X; 112530Y (2020) https://doi.org/10.1117/12.2547189
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Morphological changes in tissue are highly correlated with progression of cancer. Such structural changes lead to fluctuations of refractive index (RI) inside the tissue, which are random and exhibit self-similar properties. Depth distribution in RI of oral tissue samples were studied through Fourier domain low coherence interferometry. A halogen tungsten lamp was used as the source, and an Ocean Optics spectrometer was used for the collection of interference spectra. The experimental system was calibrated using mica sheets of different thick- nesses, polystyrene microspheres and polydimethylsiloxane (PDMS). Multifractal detrended fluctuation analysis (MFDFA) were employed on interference spectra to study and quantify multifractality in depth-wise distribution of the RI in oral tissue sections. The derived multifractal parameters, namely the generalized Hurst exponent and the width of the multifractal spectrum, showed quite significant differences among tissues having three different grades of cancer. The depth-wise variation of the refractive index showed an increase in multifractality with increasing pathological grades of cancer.

Citation Download Citation

Gyana Ranjan Sahoo, Dipti Bharti, and Asima Pradhan "Multifractal analysis of low coherence spectra for oral cancer detection", Proc. SPIE 11253, Biomedical Applications of Light Scattering X, 112530Y (21 February 2020); https://doi.org/10.1117/12.2547189

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available