Fluorescence Lifetime Imaging (FLIm) for intraoperative pathology detection in transoral robotic surgery (Conference Presentation)

Brent W. Weyers; Mark Marsden; Tianchen Sun; Julien Bec; Arnaud F. Bewley; Regina F. Gandour-Edwards; Michael G. Moore; D. Gregory Farwell; Laura Marcu

doi:10.1117/12.2545150

9 March 2020 Fluorescence Lifetime Imaging (FLIm) for intraoperative pathology detection in transoral robotic surgery (Conference Presentation)

Brent W. Weyers, Mark Marsden, Tianchen Sun, Julien Bec, Arnaud F. Bewley, Regina F. Gandour-Edwards, Michael G. Moore, D. Gregory Farwell, Laura Marcu

Author Affiliations +

Proceedings Volume 11229, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVIII; 1122902 (2020) https://doi.org/10.1117/12.2545150
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

In this work, we evaluate the potential for Fluorescence Lifetime Imaging (FLIm) to complement a surgeon's visual, endoscopic, and pathologic assessment of the adequacy of intraoperative tumor resection in clinical cancer applications of the oral cavity and oropharynx. Using a custom-built FLIm instrument during both non-robotic and robotic assisted surgical procedures, we show that intrapatient contrast between healthy and tumor tissue can be achieved intraoperatively in vivo prior to cancer resection with statistical significance (p<0.001) in 9/9 patients using at least 1/6 FLIm parameters, and ex vivo for surgically excised specimens (p<0.001) for 8/9 patients. We employ a multi-parameter linear discriminant analysis approach to demonstrate superior pathology discrimination ability through leveraging a weighted combination of all FLIm metrics. We also highlight interpatient comparisons to evaluate how FLIm signatures vary across different patients and disparate tissue anatomies.

Conference Presentation

Citation Download Citation

Brent W. Weyers, Mark Marsden, Tianchen Sun, Julien Bec, Arnaud F. Bewley, Regina F. Gandour-Edwards, Michael G. Moore, D. Gregory Farwell, and Laura Marcu "Fluorescence Lifetime Imaging (FLIm) for intraoperative pathology detection in transoral robotic surgery (Conference Presentation)", Proc. SPIE 11229, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVIII, 1122902 (9 March 2020); https://doi.org/10.1117/12.2545150

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KEYWORDS

Tissues

Pathology

Fluorescence lifetime imaging

Robotic surgery

Cancer

Tumors

Endoscopy

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