Cancer PDT vaccines: progress and prospects (Conference Presentation)

Mladen Korbelik

doi:10.1117/12.2528211

14 August 2019 Cancer PDT vaccines: progress and prospects (Conference Presentation)

Mladen Korbelik

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 110703N (2019) https://doi.org/10.1117/12.2528211
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

Therapeutic cancer vaccines work by boosting the immune system’s ability to defend the body from existing oncologic growth. Because of the well established characteristics of photodynamic therapy (PDT) to promote the immune response against targeted tumor, the standard direct PDT treatment of lesions in patients is often referred to as the vaccination in situ as the vaccine is generated in vivo exploiting antigens available at the tumor site. An alternative approach is the ex vivo generation of PDT vaccine, where surgically removed tumor treated by PDT in vitro serves as the vaccine material that is administered to the original host to eradicate residual malignant deposits. This second approach has certain advantages since it avoids certain inflammatory and other negative aspects of host response to PDT. Recent research progress has brought significant advances in the understanding of the nature of interaction of PDT with immune system. It is now clear that the critical determinant is the engagement of stress signaling networks by PDT-induced insult in targeted cancer cells. This ensures the expression of immunogenic cell death (ICD), abundant exposure of tumor antigens (including neoantigens) and espousal of damage-associated molecular patterns (DAMPs). Important advancements towards clinical translation of PDT vaccines include the identification of highly effective adjunct immunoadjuvants and strategies of controlling immunoregulatory activity. Both these elements are critical for optimizing the strength of vaccine-elicited antitumor immune response and its duration in order to ensure clinical efficacy.

Conference Presentation

Citation Download Citation

Mladen Korbelik "Cancer PDT vaccines: progress and prospects (Conference Presentation)", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110703N (14 August 2019); https://doi.org/10.1117/12.2528211

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Photodynamic therapy

Cancer

Tumors

Cell death

Defense and security

In vitro testing

Keywords/Phrases

Search In:

Publication Years