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14 August 2019 Reactive oxygen species goes beyond photodynamic therapy (Conference Presentation)
Xiaoyuan Chen
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Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 110701K (2019) https://doi.org/10.1117/12.2525919
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States
Abstract
The reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of synergistic effects between light, a photosensitizer (PS) and oxygen, which greatly favors the spatiotemporal control of the treatment. This procedure has also evoked several unresolved challenges at different levels including (i) the limited penetration depth of light, which restricts traditional PDT to superficial tumors; (ii) oxygen reliance does not allow PDT treatment of hypoxic tumors; (iii) light can complicate the phototherapeutic outcomes because of the concurrent heat generation; (iv) specific delivery of PSs to sub-cellular organelles for exerting effective toxicity remains an issue; and (v) side effects from undesirable white-light activation and self-catalyzation of traditional PSs. In this talk, the current status and the possible opportunities of nanomedicine for ROS generation for cancer therapy will be discussed in detail.
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Xiaoyuan Chen "Reactive oxygen species goes beyond photodynamic therapy (Conference Presentation)", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110701K (14 August 2019); https://doi.org/10.1117/12.2525919
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KEYWORDS
Photodynamic therapy
Oxygen
Tumors
Cancer
Nanomedicine
Picosecond phenomena
Toxicity
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