Multimodal multiphoton tomograph using a compact femtosecond fiber laser

Karsten König; Ana Batista; Aisada König; Hans Georg Breunig

doi:10.1117/12.2509551

22 February 2019 Multimodal multiphoton tomograph using a compact femtosecond fiber laser

Karsten König, Ana Batista, Aisada König, Hans Georg Breunig

Author Affiliations +

Proceedings Volume 10882, Multiphoton Microscopy in the Biomedical Sciences XIX; 108821A (2019) https://doi.org/10.1117/12.2509551
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Multiphoton tomography based on near infrared femtosecond laser technology has become a versatile high-resolution clinical- and research-imaging tool. Here, we report on a novel moveable multimodal tomograph, the MPTcompact, based on an ultracompact chiller-free fiber-laser system. The tomograph provides in vivo optical biopsies with subcellular resolution as well as optical metabolic imaging capability based on two-photon autofluorescence, second harmonic generation, fluorescence lifetime imaging, reflectance confocal microscopy, and white light CCD imaging. Applications include cancer detection, skin research, cornea research, and in situ evaluation of anti-ageing drugs and pharmaceuticals.

Citation Download Citation

Karsten König, Ana Batista, Aisada König, and Hans Georg Breunig "Multimodal multiphoton tomograph using a compact femtosecond fiber laser", Proc. SPIE 10882, Multiphoton Microscopy in the Biomedical Sciences XIX, 108821A (22 February 2019); https://doi.org/10.1117/12.2509551

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