High frequency traveling wave elastography of the cornea and sclera using a vibrating piezoelectric probe (Conference Presentation)

Antoine Ramier; Behrouz Tavakol; Seok-Hyun Yun

doi:10.1117/12.2508760

13 March 2019 High frequency traveling wave elastography of the cornea and sclera using a vibrating piezoelectric probe (Conference Presentation)

Antoine Ramier, Behrouz Tavakol, Seok-Hyun Yun

Author Affiliations +

Proceedings Volume 10880, Optical Elastography and Tissue Biomechanics VI; 1088011 (2019) https://doi.org/10.1117/12.2508760
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Optical coherence tomography-based elastography (OCE) can perform localized, quantitative measurements of biomechanical properties. One of the most promising applications of OCE is to measure corneal stiffness, which has been linked to keratoconus, corneal crosslinking, and laser vision correction, and can help improve diagnosis, screening and treatment monitoring. Various techniques have been demonstrated to determine the speed of elastic waves traveling in the cornea and thereby to measure the shear modulus of corneal tissues. Here we present a new approach based on a contact probe with a piezo-electrically vibrating tip. This wave generation approach is robust, provides extensive control over the temporal and spectral profiles of the mechanical stimulus, and allows us to measure traveling wave velocities a frequency range of 1 to 15 kHz. The shorter wavelengths obtained at high frequencies can improve the resolution of traveling wave elastography and enable measurements of stiffer tissues such as the sclera. Direct contact with the corneal surface are routinely performed for intraocular pressure measurements, which suggest that this approach has a path to clinical translation. Interestingly, we found that mechanical stimulation tends to excite a combination of guided and non-guided elastic waves, which must be considered for accurate calculation of the shear modulus and may affect other OCT elastography techniques.

Conference Presentation

Citation Download Citation

Antoine Ramier, Behrouz Tavakol, and Seok-Hyun Yun "High frequency traveling wave elastography of the cornea and sclera using a vibrating piezoelectric probe (Conference Presentation)", Proc. SPIE 10880, Optical Elastography and Tissue Biomechanics VI, 1088011 (13 March 2019); https://doi.org/10.1117/12.2508760

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available