Laser-direct-writing to enable filtration in paper-based devices

Panagiotis P. Galanis; Peijun J. W. He; Ioannis N. Katis; Michael R. Thomas; Yunlei Xianyu; Molly M. Stevens; Robert W. Eason; Collin L. Sones

doi:10.1117/12.2508753

4 March 2019 Laser-direct-writing to enable filtration in paper-based devices

Panagiotis P. Galanis, Peijun J. W. He, Ioannis N. Katis, Michael R. Thomas, Yunlei Xianyu, Molly M. Stevens, Robert W. Eason, Collin L. Sones

Author Affiliations +

Proceedings Volume 10875, Microfluidics, BioMEMS, and Medical Microsystems XVII; 108750P (2019) https://doi.org/10.1117/12.2508753
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

We report the use of a laser-based direct-write (LDW) technique that allows the fabrication of porous barriers, which enable in-line filtration within a paper-based microfluidic device. The barriers were produced within porous substrates, namely nitrocellulose membranes, via local deposition of a photo-polymer that was subsequently polymerised by exposure from a laser source. Adjustment of the photo-polymer deposition parameters determines the porosity of the barriers, which, when carefully designed and integrated within a fluidic channel, can act as filters that enable either complete blocking, selective flow or controlled separation of particles of different sizes within a fluid travelling through the channel. We have successfully identified the fabrication parameters for the creation of barriers that allow the filtration of two different types of particles, Au-nanoparticles with sizes of 40, 100 and 200 nm and latex microbeads with sizes of 200 nm and 1 μm, dispersed within an aqueous solution. We also report the use of a variable-porosity barrier for selective separation of latex microbeads from Aunanoparticles, thereby showing the usefulness of this technique for enabling in-line filtration in such paper-based microfluidic devices.

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Panagiotis P. Galanis, Peijun J. W. He, Ioannis N. Katis, Michael R. Thomas, Yunlei Xianyu, Molly M. Stevens, Robert W. Eason, and Collin L. Sones "Laser-direct-writing to enable filtration in paper-based devices", Proc. SPIE 10875, Microfluidics, BioMEMS, and Medical Microsystems XVII, 108750P (4 March 2019); https://doi.org/10.1117/12.2508753

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