PDT Dosimetry And Response

W. R. Potter

doi:10.1117/12.978008

13 June 1989 PDT Dosimetry And Response

W. R. Potter

Proceedings Volume 1065, Photodynamic Therapy: Mechanisms; (1989) https://doi.org/10.1117/12.978008
Event: OE/LASE '89, 1989, Los Angeles, CA, United States

Abstract

Determination of the dependence of Photofrin II concentration on the time integrated space irradiance in tissue allows the definition of Photodynamic dose to be formulated as an integral of sensitizer concentration over the time integrated space irradiance at each point in tissue. This integral, together with a measurement of the depth of necrosis produced by the clinically measurable sensitizer and light doses, and the tissue optical properties allows the calculation of the expected necrotic depth for any similar tissue. These predictive calculations are carried out for various dosimetric conditions and a variety of clinically interesting sources e.g. long cylinders or spherically symmetric sources imbedded in the tissue, uniform surface illumination over a wide field or a spherical source at the center of a water filled bladder. The results are presented in graphical form and are based on published clinical data.

Citation Download Citation

W. R. Potter "PDT Dosimetry And Response", Proc. SPIE 1065, Photodynamic Therapy: Mechanisms, (13 June 1989); https://doi.org/10.1117/12.978008

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