Diffuse reflectance spectroscopy for in-vivo stomach and oesophageal tissue classification during upper gastrointestinal cancer surgery

Ioannis Gkouzionis; Scarlet Nazarian; Nisha Patel; Ara Darzi; Christopher J. Peters; Daniel S. Elson

doi:10.1117/12.2649625

6 March 2023 Diffuse reflectance spectroscopy for in-vivo stomach and oesophageal tissue classification during upper gastrointestinal cancer surgery

Ioannis Gkouzionis, Scarlet Nazarian, Nisha Patel, Ara Darzi, Christopher J. Peters, Daniel S. Elson

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Proceedings Volume PC12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI; PC123680M (2023) https://doi.org/10.1117/12.2649625
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Cancers of the upper gastrointestinal (GI) tract remain a major contributor to overall cancer risk. This study uses a sterilisable diffuse reflectance spectroscopic probe for tissue characterisation intraoperatively during stomach and oesophageal cancer surgery. Histopathology correlation is achieved by the surgeon marking the optical probed tissue locations after the acquisition of spectral data. The data is normalised, and significant features are selected to improve tissue discrimination accuracy. Supervised classification algorithms are used for discrimination between tumour and non-tumour tissue and evaluated in terms of accuracy, sensitivity, specificity, and the area under the curve.

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Ioannis Gkouzionis, Scarlet Nazarian, Nisha Patel, Ara Darzi, Christopher J. Peters, and Daniel S. Elson "Diffuse reflectance spectroscopy for in-vivo stomach and oesophageal tissue classification during upper gastrointestinal cancer surgery", Proc. SPIE PC12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI, PC123680M (6 March 2023); https://doi.org/10.1117/12.2649625

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KEYWORDS

Cancer

Tissue optics

Surgery

Diffuse reflectance spectroscopy

Stomach

In vivo imaging

Tissues

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