Aleksander Sobolewski,1 Gaël Barthet,1 Hubert van den Bergh,2 Corinne Brana,1 Filipa Ferreira,1 Michalina Górahttps://orcid.org/0000-0002-1200-3511,1 George Kouvas,3 Salvatore Novello,2 Jules Scholler,1 Mélanie Sipion,1 Hilal Lashuel4
1Wyss Ctr. for Bio and Neuro Engineering (Switzerland) 2Ecole Polytechnique Fédérale de Lausanne (Switzerland) 3Wyss Center for Bio and Neuroengineering (Switzerland) 4École Polytechnique Fédérale de Lausanne (EPFL) (Switzerland)
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Near-infrared photobiomodulation has been reported to have therapeutic effects in several murine Alzheimer’s disease models. As a translational institution we sought to confirm and elaborate on these findings in a blind experiment study following GLP principles. 5xFAD mice were subjected to 810 nm transcutaneous LED photobiomodulation from one to six months of age with 0 (sham), 6 or 600 mW/cm2 power density. The effects - including dependence on light power values - were investigated with a battery of memory tests (novel object recognition, Y-maze and Morris water maze) and immunohistochemical and biochemical analyses (including ABeta plaque burden, neuronal count and inflammatory markers).
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Aleksander Sobolewski, Gaël Barthet, Hubert van den Bergh, Corinne Brana, Filipa Ferreira, Michalina Góra, George Kouvas, Salvatore Novello, Jules Scholler, Mélanie Sipion, Hilal Lashuel, "Effects of long-term photobiomodulation on 5xFAD murine model of Alzheimer disease in a sham-controlled blind experiment study," Proc. SPIE PC12362, Mechanisms of Photobiomodulation Therapy XVII, PC1236209 (17 March 2023); https://doi.org/10.1117/12.2649711