Rishyashring "Rishee" Iyer is a postdoctoral associate at UC San Diego, working under the guidance of Prof. David Kleinfeld, on optical imaging of neurovascular coupling in mice. Rishee completed his Ph.D. in Electrical and Computer Engineering from the University of Illinois Urbana-Champaign in 2024 advised by Prof. Stephen Boppart for his thesis titled "Label-free optical imaging of neural activity", where he developed several tools for fast multimodal label-free imaging of neurometabolism and biomechanics following neuronal activity. Rishee also has a M.Eng. in Biomedical Engineering from Cornell University, where he worked with Prof. Steven Adie on optical coherence elastography and computational optics.
Rishee's research interests lie at the intersection of optics, neuroscience, and mechanobiology. He was awarded the Schmidt Science Fellowship in 2024 to pursue a disciplinary shift from optical engineering to mechanobiology for his postdoctoral research.
Rishee's research interests lie at the intersection of optics, neuroscience, and mechanobiology. He was awarded the Schmidt Science Fellowship in 2024 to pursue a disciplinary shift from optical engineering to mechanobiology for his postdoctoral research.
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Innovations in each modality improved the overall speed and sensitivity. Fast fluorescence lifetime imaging microscopy (FLIM) was accelerated with our computational photon counting algorithm called single-and-multi photon peak event detection (SPEED), capable of counting up to 250% photon rates. Dual-channel fast two-photon FLIM was achieved by compressed sensing of analog photocurrents on a field-programmable gate array on board the digitizer. We developed a new and faster method for hyperspectral coherent Raman microscopy using supercontinuum generation and custom pulse shapers, which facilitated rapid tuning to desired vibrational states. Polarization multiplexing in optical coherence imaging enabled compressed sensing of birefringence. Finally, computational approaches to maximize the information from these complementary contrasts yielded new insights into the processes within the tissue microenvironment. VAMPIRE microscopy is the nexus of label-free microscopy research, advances in optoelectronic technologies, and our innovations in computational and multimodal imaging for diverse applications.
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