Prof. Seok-Hyun Andy Yun Profile

Prof. Seok-Hyun Andy Yun

Professor at Wellman Ctr for Photomedicine

SPIE Involvement:

Conference Program Committee | Author | Editor

Publications (28)

Proceedings Article | 13 March 2024 Presentation

In vivo stiffness measurement of epidermis, dermis, and hypodermis using broadband Rayleigh-wave optical coherence elastography

Xu Feng, Guo-Yang Li, Antoine Ramier, Amira Eltony, Seok-Hyun Yun

Proceedings Volume PC12844, PC1284402 (2024) https://doi.org/10.1117/12.2691018

KEYWORDS: Optical coherence, Elastography, In vivo imaging, Tissues, Skin, Elasticity, Spatial resolution, Natural surfaces, Finite element methods, Biomechanics

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Proceedings Article | 13 March 2024 Presentation

Ultra-wideband optical coherence elastography from acoustic to ultrasonic frequencies

Xu Feng, Guo-Yang Li, Seok-Hyun Yun

Proceedings Volume PC12830, PC1283026 (2024) https://doi.org/10.1117/12.2691484

KEYWORDS: Tissues, Algorithm development, Acoustic waves, Visualization, Visual analytics, Viscoelasticity, Acoustics, Ultrasonics, Optical coherence, Elastography

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Proceedings Article | 13 March 2024 Presentation

Translational development of antimicrobial blue light for wound infection control: new therapeutic window, treatment regimen, and wearable device

Jie Hui, Wonjoon Moon, Pu-Ting Dong, Carolina dos Anjos, Laisa Negri, Hao Yan, Ying Wang, Joshua Tam, Tianhong Dai, Rox Anderson, Jeremy Goverman, Jeff Gelfand, Seok-Hyun Andy Yun

Proceedings Volume PC12822, PC128220I (2024) https://doi.org/10.1117/12.3001119

KEYWORDS: Skin, Control systems, In vivo imaging, Wound healing, Thermal effects, Resistance, Light sources and illumination, Biomedical applications, Windows, Wearable devices

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Proceedings Article | 12 March 2024 Presentation + Paper

Enhancing signal-to-noise ratio in stimulated Brillouin microscopy with low duty cycle nanosecond pulses

Desmond Chow, Seok-Hyun Yun

Proceedings Volume 12854, 128540D (2024) https://doi.org/10.1117/12.2692239

KEYWORDS: Tissue optics, Elastography, Light scattering, Pulsed laser operation, Signal processing, Continuous wave operation, Laser scattering, Microscopy, Pulse signals, Signal to noise ratio

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SPIE Journal Paper | 1 September 2023 Open Access

Precise photoelectrochemical tuning of semiconductor microdisk lasers

Debarghya Sarkar, Paul Dannenberg, Nicola Martino, Kwon-Hyeon Kim, Yue Wu, Seok-Hyun Yun

AP, Vol. 5, Issue 05, 056004, (September 2023) https://doi.org/10.1117/12.10.1117/1.AP.5.5.056004

KEYWORDS: Etching, Semiconductor lasers, Semiconductors, Light sources and illumination, Emission wavelengths, Video, Particles, Scanning electron microscopy, Laser applications, Silica

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Proceedings Article | 17 March 2023 Presentation

High-precision single-mode microdisk laser particle arrays by controlled photoelectrochemical tuning over wide spectral range

Debarghya Sarkar, Nicola Martino, Kwon-Hyeon Kim, Seok-Hyun Yun

Proceedings Volume PC12407, PC1240705 (2023) https://doi.org/10.1117/12.2650543

KEYWORDS: Etching, Particles

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Proceedings Article | 2 March 2022 Presentation + Paper

Investigating scleral crosslinking to stop myopia progression using optical coherence elastography

Maria Viñas-Peña, Xu Feng, Guoyang Li, Seok-Hyun Yun

Proceedings Volume 11962, 1196202 (2022) https://doi.org/10.1117/12.2608233

KEYWORDS: Sclera, Tissue optics, Coherence (optics), Elastography, Tissues, Eye, Collagen, Optical coherence tomography

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Scleral collagen crosslinking (SCXL) to mechanically reinforce the scleral tissue and modify axial length is the most promising novel technique to treat Myopia. In this study, we use Optical coherence elastography (OCE) and mechanical testing to evaluate the impact of SCXL on different posterior scleral locations, by quantifying the shear and Young’s modulus, to characterize the biomechanical properties of posterior sclera that are better suited for a higher impact of the SCXL. 15 porcine eyes were treated with riboflavin-ultraviolet-A irradiation (UVX-SCXL). Rayleigh-wave speed was measured: (1) before treatment, (2) after 30 minutes soaking on riboflavin, (3) after UVX-SCXL treatment, and (4) after treatment in a non-treated area. Uniaxial tensile tests were performed on scleral strips. Shear and Young modulus were obtained for all conditions. Mean wave speed (WS) and shear modulus (G) for posterior sclera differed statistically for the different locations, being the POST-POST higher than POST-ANT, both in temporal (WS 85% and G ↑124%, p<0.05) and nasal (WS ↑124%, p<0.01 and G ↑160%, p<0.01) positions. UVX-SCXL treatment changed significantly the mechanical properties of posterior sclera, with higher changes induced at the most posterior locations (POST-ANT WS= 22.95±1.15 (m/s) T↑130% N↑146% and POST-POST WS= 26.28±1.41 (m/s) T↑142% N↑132%, p<0.01, averaged across frequencies)). Both shear and Young’s modulus significantly increased after treatment (averaged across eyes: G T↑249% N↑193% and E T↑320% N↑208%, p<0.01). OCE is a noninvasive, high-resolution tool to evaluate the impact of SCXL ex vivo, and in vivo in the future. Differences in posterior scleral properties should be considered to maximize the impact of UVX-SCXL treatment. UVX-SCXL in porcine scleras changes significantly the biomechanical properties and strengthen the scleral tissue. Future work will consist on the evaluation of the biomechanical and microstructural changes in posterior sclera following SCXL in myopic eyes.

Proceedings Article | 5 March 2021 Presentation

Measuring mechanical anisotropy of the cornea with Brillouin microscopy

Amira Eltony, Peng Shao, Seok-Hyun Yun

Proceedings Volume 11645, 1164517 (2021) https://doi.org/10.1117/12.2584263

KEYWORDS: Cornea, Anisotropy, Microscopy, Tissues, Optical fibers, Collagen, Transmission electron microscopy, Optical microscopy, Microscopes, In vivo imaging

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Proceedings Article | 13 March 2019 Presentation

High frequency traveling wave elastography of the cornea and sclera using a vibrating piezoelectric probe (Conference Presentation)

Antoine Ramier, Behrouz Tavakol, Seok-Hyun Yun

Proceedings Volume 10880, 1088011 (2019) https://doi.org/10.1117/12.2508760

KEYWORDS: Elastography, Cornea, Sclera, Tissues, Coherence (optics), Laser vision correction, Velocity measurements, Natural surfaces, Optical coherence tomography

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Proceedings Article | 7 March 2019 Presentation

Mapping the phase and amplitude of ossicular chain motion using sound-synchronous optical coherence vibrography (Conference Presentation)

Antoine Ramier, Jeffrey Tao Cheng, Michael Ravicz, John Rosowski, Seok-Hyun Yun

Proceedings Volume 10853, 1085304 (2019) https://doi.org/10.1117/12.2506540

KEYWORDS: Vibrometry, Mechanics, Acoustics, Data acquisition, Optical coherence tomography, Coherence (optics), Ear

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Proceedings Article | 2 May 2017 Presentation

Rapid non-invasive mechanical imaging using line-scanning Brillouin microscopy (Conference Presentation)

Jitao Zhang, Antonio Fiore, Seok-Hyun Yun, Hanyoup Kim, Giuliano Scarcelli

Proceedings Volume 10067, 100670G (2017) https://doi.org/10.1117/12.2252143

KEYWORDS: Phased arrays, Mechanical efficiency, Phased array optics, Statistical analysis, Biological research, Spectroscopy, Spectrometers, Tissue optics, Light scattering, Microscopy

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Proceedings Article | 24 April 2017 Presentation

Selective two-photon collagen crosslinking in situ measured by Brillouin microscopy (Conference Presentation)

Sheldon J. Kwok, Ivan Kuznetsov, Moonseok Kim, Myunghwan Choi, Giuliano Scarcelli, Seok-Hyun Yun

Proceedings Volume 10067, 100670M (2017) https://doi.org/10.1117/12.2251565

KEYWORDS: Microfabrication, Photonic microstructures, Two photon polymerization, In situ metrology, Confocal microscopy, Femtosecond phenomena, Cornea, Microscopy, Tissues, Collagen

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Proceedings Article | 19 April 2017 Presentation

Flexible polymer waveguides for light-activated therapy (Conference Presentation)

Moonseok Kim, Sheldon J. Kwok, Harvey Lin, Dong Hee Lee, Seok Hyun Yun

Proceedings Volume 10058, 1005807 (2017) https://doi.org/10.1117/12.2251643

KEYWORDS: Light scattering, Tissues, Light wave propagation, Tissue optics, Collagen, Photodynamic therapy, Phototherapy, Polymers, Polymer multimode waveguides, Waveguides

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Proceedings Article | 27 April 2016 Presentation

A Fabry-Perot etalon-based notch filter for background cleaning in Brillouin microscopy (Conference Presentation)

Peng Shao, Sebastien Besner, Giuliano Scarcelli, Seok-Hyun Yun

Proceedings Volume 9710, 97100H (2016) https://doi.org/10.1117/12.2212629

KEYWORDS: Volume holography, Optical components, Photomedicine, Scattering, Laser scattering, Microscopy, Dielectric filters, Linear filtering, Optical filters, Fabry–Perot interferometers

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Proceedings Article | 27 April 2016 Presentation

Ultra-high spectral extinction Brillouin spectroscopy for turbid tissue measurements (Conference Presentation)

Jitao Zhang, Antonio Fiore, Peng Shao, Seok-Hyun Yun, Giuliano Scarcelli

Proceedings Volume 9710, 97100F (2016) https://doi.org/10.1117/12.2211794

KEYWORDS: Phased array optics, Photomedicine, Bandpass filters, Phased arrays, Light scattering, Fabry–Perot interferometry, Biomedical optics, Tissue optics, Signal attenuation, Spectroscopy

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Proceedings Article | 26 April 2016 Presentation

Biological lasers for BIOS (Conference Presentation)

Seok-Hyun Yun

Proceedings Volume 9700, 97000K (2016) https://doi.org/10.1117/12.2220767

KEYWORDS: Current controlled current source, Biomedical optics

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Proceedings Article | 26 April 2016 Presentation

Imaging of Keratoconic and normal human cornea with a Brillouin imaging system (Conference Presentation)

Sebastien Besner, Peng Shao, Giuliano Scarcelli, Roberto Pineda, Seok-Hyun (Andy) Yun

Proceedings Volume 9693, 96930W (2016) https://doi.org/10.1117/12.2212601

KEYWORDS: Phased arrays, Biological detection systems, In vivo imaging, Systems engineering, Mechanical engineering, Detector development, Eye, Cones, Imaging systems, Cornea

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Proceedings Article | 11 March 2015 Paper

Biocompatible optical needle array for antibacterial blue light therapy

Caio Guimarães, Jeesoo An, Matjaz Humar, Will Goth, Andy Yun

Proceedings Volume 9341, 93410R (2015) https://doi.org/10.1117/12.2083384

KEYWORDS: Optics manufacturing, Microscopes, Tissues, Light scattering, Light emitting diodes, Optical properties, Skin, Phototherapy, Optical arrays, Tissue optics

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SPIE Journal Paper | 29 April 2013 Open Access

350-μm side-view optical probe for imaging the murine brain in vivo from the cortex to the hypothalamus

Jun Ki Kim, Jin Woo Choi, Seok Hyun Yun

JBO, Vol. 18, Issue 05, 050502, (April 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.5.050502

KEYWORDS: Brain, Neuroimaging, In vivo imaging, Tissue optics, Tissues, Brain imaging, Blood vessels, Optical imaging, Neurons, Visualization

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Proceedings Article | 17 October 2012 Paper

GRIN microendoscopes for high resolution in-vivo fluorescence imaging in small animals

Jun Ki Kim, Seok-Hyun Yun

Proceedings Volume 8421, 84211P (2012) https://doi.org/10.1117/12.970382

KEYWORDS: Image visualization, Ultraviolet radiation, Visualization, Preclinical imaging, Image resolution, Luminescence, Relays, In vivo imaging, GRIN lenses, Endoscopes

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Proceedings Article | 26 August 2009 Paper

Fluorescence ghost imaging

Giuliano Scarcelli, Seok Hyun Yun

Proceedings Volume 7465, 746503 (2009) https://doi.org/10.1117/12.824390

KEYWORDS: Luminescence, Signal detection, Crystals, Photonic crystal devices, Light sources, Imaging spectroscopy, Photonic crystals, Photodetectors, Molecules, Sensors

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Proceedings Article | 13 July 2009 Paper

Intravital fiber-optic fluorescence imaging for monitoring ovarian carcinoma progression and treatment response

Bryan Spring, Jonathan Celli, Conor Evans, Wei Zhong, Imran Rizvi, Zhiming Mai, Jerome Mertz, Seok Yun, Tayyaba Hasan

Proceedings Volume 7380, 73800L (2009) https://doi.org/10.1117/12.828206

KEYWORDS: Tumors, Luminescence, Photodynamic therapy, Fiber optics, Ovarian cancer, Picosecond phenomena, Tumor growth modeling, 3D modeling, Image processing, In vivo imaging

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SPIE Journal Paper | 1 January 2008 Open Access

In vivo confocal and multiphoton microendoscopy

Pilhan Kim, Mehron Pouris'haag, Daniel Cote, Charles Lin, Seok-Hyun Yun

JBO, Vol. 13, Issue 01, 010501, (January 2008) https://doi.org/10.1117/12.10.1117/1.2839043

KEYWORDS: Confocal microscopy, Luminescence, Endoscopes, In vivo imaging, GRIN lenses, Image resolution, Imaging systems, Endoscopy, Second-harmonic generation, Objectives

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SPIE Journal Paper | 1 November 2007 Open Access

Multimodality optical imaging of embryonic heart microstructure

Ronit Yelin, Dvir Yelin, William Oh, Seok-Hyun Yun, Caroline Boudoux, Benjamin Vakoc, Brett Bouma, Guillermo Tearney

JBO, Vol. 12, Issue 06, 064021, (November 2007) https://doi.org/10.1117/12.10.1117/1.2822904

KEYWORDS: Heart, Bioalcohols, In vivo imaging, Optical imaging, Image resolution, Confocal microscopy, Video, 3D image processing, Visualization, Optical coherence tomography

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Proceedings Article | 13 April 2005 Paper

Spectral-domain polarization-sensitive optical coherence tomography at 850 nm

Barry Cense, Teresa Chen, Mircea Mujat, Chulmin Joo, Taner Akkin, B. Park, Mark Pierce, Andy Yun, Brett Bouma, Guillermo Tearney, Johannes de Boer

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.592840

KEYWORDS: Lamps, Beam splitters, Line scan cameras, Birefringence, Eye, Phase measurement, Nerve, Retina, Polarization, Optical coherence tomography

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Proceedings Article | 9 June 2004 Paper

Biomedical imaging using optical technologies

S. Yun, Guillermo Tearney, Brett Bouma

Proceedings Volume 5502, (2004) https://doi.org/10.1117/12.566509

KEYWORDS: Absorption, Fiber optics, Tissues, Light scattering, Spatial resolution, Optical imaging, Confocal microscopy, Tissue optics, Biomedical optics, Optical coherence tomography

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Proceedings Article | 20 April 2000 Paper

Strain monitoring of a smart bridge using a fiber Bragg grating sensor system with a wavelength-swept fiber laser

Chang-Sun Hong, Chi-Young Ryu, Bon-Yono Koo, Chun-Gon Kim, Seok-Hyun Yun

Proceedings Volume 3988, (2000) https://doi.org/10.1117/12.383157

KEYWORDS: Data storage, Tunable filters, Visualization, Fiber lasers, Fabry–Perot interferometers, Composites, Signal processing, Bridges, Fiber Bragg gratings, Sensors

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Proceedings Article | 1 September 1999 Paper

Wavelength-swept mode-locked fiber laser for sensor interrogations

Seok Hyun Yun

Proceedings Volume 3746, 37462H (1999) https://doi.org/10.1117/12.2302079

KEYWORDS: Sensors, Optical filters, Fiber lasers, Mode locking, Electronic filtering, Optical fibers, Electro optical modeling, Nonlinear optics, Bandpass filters, Continuous wave operation

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Showing 5 of 28 publications

Proceedings Volume Editor (3)

SPIE Conference Volume | 10 April 2015

Bioinspired, Biointegrated, Bioengineered Photonic Devices III

SPIE Conference Volume | 1 April 2014

Bioinspired, Biointegrated, Bioengineered Photonic Devices II

SPIE Conference Volume | 26 March 2013

Bioinspired, Biointegrated, Bioengineered Photonic Devices

Conference Committee Involvement (18)

Optical Elastography and Tissue Biomechanics XII

25 January 2025 | San Francisco, California, United States

Optical Elastography and Tissue Biomechanics XI

27 January 2024 | San Francisco, California, United States

Optical Elastography and Tissue Biomechanics X

28 January 2023 | San Francisco, California, United States

Optical Elastography and Tissue Biomechanics IX

22 January 2022 | San Francisco, California, United States

Optical Elastography and Tissue Biomechanics VIII

6 March 2021 | Online Only, California, United States

Optical Elastography and Tissue Biomechanics VII

1 February 2020 | San Francisco, California, United States

Optical Coherence Imaging Techniques and Imaging in Scattering Media

25 June 2019 | Munich, Germany

Optical Elastography and Tissue Biomechanics VI

2 February 2019 | San Francisco, California, United States

Optical Elastography and Tissue Biomechanics V

27 January 2018 | San Francisco, California, United States

Optical Coherence Imaging Techniques and Imaging in Scattering Media II

25 June 2017 | Munich, Germany

Optical Elastography and Tissue Biomechanics IV

28 January 2017 | San Francisco, California, United States

Optical Elastography and Tissue Biomechanics III

13 February 2016 | San Francisco, California, United States

SPIE Micro+Nano Materials, Devices, and Systems

7 December 2015 | Sydney, New South Wales, Australia

Bioinspired, Biointegrated, Bioengineered Photonic Devices III

7 February 2015 | San Francisco, California, United States

Optical Elastography and Tissue Biomechanics II

7 February 2015 | San Francisco, California, United States

Bioinspired, Biointegrated, Bioengineered Photonic Devices II

1 February 2014 | San Francisco, California, United States

Optical Elastography and Tissue Biomechanics

1 February 2014 | San Francisco, California, United States

Bioinspired, Biointegrated, Bioengineered Photonic Devices

2 February 2013 | San Francisco, California, United States

Showing 5 of 18 Conference Committees

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