Dr. Vinh Nguyen Du Le Profile

Dr. Vinh Nguyen Du Le

Assistant Professor at Univ of Alabama in Huntsville

SPIE Involvement:

Author

Area of Expertise:

Optical Spectroscopy , Diffuse Optics , Microscopy

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Profile Summary

Dr. Le is an Assistant Professor at UAH. Visit Dr. Le's lab website for more details.

Publications (21)

Proceedings Article | 10 May 2024 Presentation

Time-of-flight photoplethysmography (TOF-PPG) offers accurate and robust monitoring of heart rate

V. N. Du Le

Proceedings Volume 12951, 1295119 (2024) https://doi.org/10.1117/12.3012188

KEYWORDS: Photoplethysmography, Heart, Skin, Photons, Wearable devices, Tissue optics, Monte Carlo methods, Geometrical optics, Continuous wave operation, Chemical vapor deposition

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SPIE Journal Paper | 27 January 2024 Open Access

Speculum-free portable preterm imaging system

Tananant Boonya-ananta, Mariacarla Gonzalez, Ajmal Ajmal, Vinh Nguyen Du Le, Edward DeHoog, Michael Paidas, Arumugam Jayakumar, Jessica Ramella-Roman

JBO, Vol. 29, Issue 05, 052918, (January 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.5.052918

KEYWORDS: Imaging systems, Polarization, Portability, Cervix, Cameras, Silicon, Design, Light emitting diodes, Depolarization, Light sources and illumination

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Proceedings Article | 30 May 2022 Presentation

Preterm birth risk assessment with imaging Mueller polarimetry: mice model of pregnancy

Hee Ryung Lee, Ilyas Saytashev, Vinh Nguyen Du Le, Mala Mahendroo, Jessica Ramella-Roman, Tatiana Novikova

Proceedings Volume PC12147, PC121470D (2022) https://doi.org/10.1117/12.2622746

KEYWORDS: Polarimetry, Collagen, Mouse models, Optical fibers, Cervix, Statistical analysis, Microscopy, Tissues, Tissue optics, Surgery

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SPIE Journal Paper | 29 March 2022 Open Access

Skin optical properties in the obese and their relation to body mass index: a review

Andres Rodriguez, Mel Tananant Boonya-Ananta, Mariacarla Gonzalez, Vinh Nguyen Du Le, Jesse Fine, Cristina Palacios, Mike McShane, Gerard Coté, Jessica Ramella-Roman

JBO, Vol. 27, Issue 03, 030902, (March 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.3.030902

KEYWORDS: Skin, Collagen, Scattering, Absorption, Tissues, Optical properties, Brain-machine interfaces, Blood, Water, Capillaries

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Significance: Obesity is a worldwide epidemic contributing directly to several cardiovascular risk factors including hypertension and type 2 diabetes. Wearable devices are becoming better at quantifying biomarkers relevant for the management of health and fitness. Unfortunately, both anecdotal evidence and recent studies indicate that some wearables have higher levels of error when utilized by populations with darker skin tones and high body mass index (BMI). There is an urgent need for a better evaluation of the limits of wearable health technologies when used by obese individuals. Aims: (1) To review the current know-how on changes due to obesity in the skin epidermis, dermis, and subcutis that could affect the skin optical properties; (2) for the green wavelength range, to evaluate the difference in absorption and scattering coefficients from the abdominal skin between individuals with and without elevated BMI. The changes include alterations in layer thickness and cell size, as well as significant differences in chromophores and scatterer content, e.g., water, hemoglobin, collagen, and lipids. Approach: We have summarized literature pertaining to changes in skin and its components in obesity and report the results of our search using articles published between years 1971 and 2020. A linear model was used to demonstrate the absorption and reduced scattering coefficient of the abdominal skin of individuals with and without elevated BMI in the green wavelength range (530 to 550 nm) that is typically found in most wearables. Results: The general trends indicate a decrease in absorption for both dermis and subcutis and an increase in reduced scattering for both epidermis and dermis. At 544-nm wavelength, a typical wavelength used for photoplethysmography (PPG), the absorption coefficient’s relative percentage difference between high and low BMI skin, was 49% in the subcutis, 19% in the dermis, and negligible in the epidermis, whereas the reduced scattering coefficient relative difference was 21%, 29%, and 165% respectively. Conclusions: These findings suggest that there could be significant errors in the output of optical devices used for monitoring health and fitness if changes due to obesity are not accounted for in their design.

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Proceedings Article | 7 March 2022 Presentation

Detection of cervical collagen remodeling with Mueller polarimetry in mice model of pregnancy

Hee Ryung Lee, Ilyas Saytashev, Vinh Nguyen Du Le, Mala Mahendroo, Jessica Ramella-Roman, Tatiana Novikova

Proceedings Volume PC11963, PC1196309 (2022) https://doi.org/10.1117/12.2610083

KEYWORDS: Collagen, Polarimetry, Mouse models, Optical fibers, Cervix, Tissues, Tissue optics, Statistical analysis, Microscopy, Harmonic generation

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Proceedings Article | 4 March 2022 Paper

Machine learning powered Mueller matrix microscope for collagen and elastin visualization in the mouse cervix

Mariacarla Gonzalez, Camilo Roa, Arturo Jimenez, Rachelle Gomez-Guevara, V. N. Du Le, Tatiana Novikova, Jessica Ramella-Roman

Proceedings Volume 11963, 119630B (2022) https://doi.org/10.1117/12.2609978

KEYWORDS: Collagen, Digital filtering, Cervix, Visualization, Microscopes, Tissues, Machine learning, Wave plates, Polarization, Polarimetry

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Proceedings Article | 4 March 2022 Paper

A speculum free portable preterm imaging system

Tananant Boonya-Ananta, Mariacarla Gonzalez, Vinh Nguyen Du Le, Edward DeHoog, Michael Paidas, Arumugam Jayakumar, Jessica Ramella-Roman

Proceedings Volume 11963, 119630A (2022) https://doi.org/10.1117/12.2609915

KEYWORDS: Imaging systems, Cervix, Cameras, Computer aided design, Polarization, Optical components, Polarizers, Optical design, Light emitting diodes, In vivo imaging

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Proceedings Article | 2 March 2022 Presentation + Paper

In-vivo human study of skin optical properties in individuals with obesity

Andres Rodriguez, Michael Alzamora, Ajmal Ajmal, Tananant Boonya-Ananta, Vinh Nguyen Du Le, Ingemar Fredriksson, Tomas Strömberg, Jessica Ramella-Roman

Proceedings Volume 11968, 119680B (2022) https://doi.org/10.1117/12.2610464

KEYWORDS: Optical properties, Skin, Absorption, Scattering, Tissues, Oxygen, Statistical analysis, Optical sensors, In vivo imaging, Data communications

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Proceedings Article | 5 March 2021 Presentation

Synthetic photoplethysmographic waveform at the radial artery

Tananant Boonya-Ananta, Andres Rodriguez, Ajmal Ajmal, Du Le, Joshua Hutcheson, Jessica Ramella-Roman

Proceedings Volume 11640, 116400O (2021) https://doi.org/10.1117/12.2578951

KEYWORDS: Arteries, Photoplethysmography, Blood pressure, Tissue optics, Signal attenuation, Monte Carlo methods, Instrument modeling, Geometrical optics, Finite element methods, Blood

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Proceedings Article | 5 March 2021 Presentation

Auto-detection of cervical collagen and elastin in Mueller Matrix polarimetry microscopic images using K-NN and Semantic Segmentation classification

Camilo Roa, Vinh Nguyen Du Le, Jessica Ramella-Roman

Proceedings Volume 11646, 116460Z (2021) https://doi.org/10.1117/12.2578997

KEYWORDS: Tissues, Collagen, Polarimetry, Databases, Cervix, Transform theory, Statistical analysis, Polarization, Mueller matrices, Microscopy

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Proceedings Article | 5 March 2021 Presentation

Investigation of optical heart rate sensors in wearables and the influence of skin tone and obesity on photoplethysmography (PPG) signal

Ajmal Ajmal, Tananant Boonya-Ananta, Andres Rodriguez, Vinh Nguyen Du Le, Jessica Ramella-Roman

Proceedings Volume 11638, 1163808 (2021) https://doi.org/10.1117/12.2578023

KEYWORDS: Sensors, Heart, Photoplethysmography, Blood, Tissue optics, Skin, Measurement devices, Finite element methods, Monte Carlo methods

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SPIE Journal Paper | 3 February 2017 Open Access

Dual-modality optical biopsy of glioblastomas multiforme with diffuse reflectance and fluorescence: ex vivo retrieval of optical properties

Vinh Nguyen Du Le, John Provias, Naresh Murty, Michael Patterson, Zhaojun Nie, Joseph Hayward, Thomas Farrell, William McMillan, Wenbin Zhang, Qiyin Fang

JBO, Vol. 22, Issue 02, 027002, (February 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.2.027002

KEYWORDS: Luminescence, Optical properties, Tissues, Diffuse reflectance spectroscopy, Brain, Tumors, Absorption, Biopsy, Scattering, Biomedical optics

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SPIE Journal Paper | 22 December 2015 Open Access

Experimental recovery of intrinsic fluorescence and fluorophore concentration in the presence of hemoglobin: spectral effect of scattering and absorption on fluorescence

Vinh Nguyen Du Le, Michael Patterson, Thomas Farrell, Joseph Hayward, Qiyin Fang

JBO, Vol. 20, Issue 12, 127003, (December 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.12.127003

KEYWORDS: Luminescence, Absorption, Scattering, Tissues, Optical fibers, Magnesium, Mie scattering, Optical properties, Photons, Calibration

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Proceedings Article | 31 May 2013 Paper

Characterization and application of 3D-printed phantoms for biophotonic imaging

Jianting Wang, James Coburn, Chia-Pin Liang, Nicholas Woolsey, Du Le, Jessica Ramella-Roman, Yu Chen, Joshua Pfefer

Proceedings Volume 8719, 87190Y (2013) https://doi.org/10.1117/12.2018285

KEYWORDS: Absorption, Reflectivity, 3D printing, Biomedical optics, Printing, Optical coherence tomography, Tissues, Optical properties, Scattering, Hyperspectral imaging

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Proceedings Article | 20 March 2013 Paper

Monitoring the impact of pressure on the assessment of skin perfusion and oxygenation using a novel pressure device

Jessica Ramella-Roman, Thuan Ho, Du Le, Pejhman Ghassemi, Thu Nguyen, Alison Lichy, Suzanne Groah

Proceedings Volume 8576, 85760N (2013) https://doi.org/10.1117/12.2006256

KEYWORDS: Skin, Actuators, Tissue optics, Aluminum, Reflectivity, Sensors, Fiber optics, Doppler effect, Ocean optics, Spinal cord

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Proceedings Article | 13 March 2013 Paper

Spectral variations in narrow band imaging depth-selectivity: mucosal scattering vs. hemoglobin absorption

Quanzeng Wang, Du Le, Jessica Ramella-Roman, Joshua Pfefer

Proceedings Volume 8573, 85730N (2013) https://doi.org/10.1117/12.2008768

KEYWORDS: Scattering, Absorption, Tissues, Reflectivity, Capillaries, Visualization, Blood, Blood vessels, Light scattering, Monte Carlo methods

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Proceedings Article | 15 February 2013 Paper

Skin microvascular and metabolic response to pressure relief maneuvers in people with spinal cord injury

Jessica Ramella-Roman, Du Le, Pejhman Ghassemi, Thu Nguyen, Alison Lichy, Suzanne Groah

Proceedings Volume 8579, 85790R (2013) https://doi.org/10.1117/12.2006260

KEYWORDS: Skin, Injuries, Tissues, Ocean optics, Spinal cord, Doppler effect, Sensors, Fiber optics, Laser spectroscopy, Fiber lasers

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SPIE Journal Paper | 13 December 2012 Open Access

Monte Carlo modeling of light-tissue interactions in narrow band imaging

Du Le, Quanzeng Wang, Jessica Ramella-Roman, T. Joshua Pfefer

JBO, Vol. 18, Issue 01, 010504, (December 2012) https://doi.org/10.1117/12.10.1117/1.JBO.18.1.010504

KEYWORDS: Absorption, Monte Carlo methods, Scattering, Tissue optics, Tissues, Optical properties, Capillaries, Reflectivity, Instrument modeling, Blood vessels

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Proceedings Article | 16 May 2012 Paper

Quantitative evaluation of mucosal vascular contrast in narrow band imaging using Monte Carlo modeling

Du Le, Quanzeng Wang, Jessica Ramella-Roman, Joshua Pfefer

Proceedings Volume 8367, 836709 (2012) https://doi.org/10.1117/12.918375

KEYWORDS: Tissues, Absorption, Scattering, Blood, Reflectivity, Monte Carlo methods, Blood vessels, Photons, Visualization, Optical properties

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Proceedings Article | 28 February 2012 Paper

Visualization of mucosal vasculature with narrow band imaging: a theoretical study

Quanzeng Wang, Du Le, Jessica Ramella-Roman, Joshua Pfefer

Proceedings Volume 8215, 821505 (2012) https://doi.org/10.1117/12.906817

KEYWORDS: Tissues, Absorption, Visualization, Blood vessels, Scattering, Reflectivity, Blood, Photons, Monte Carlo methods, Bandpass filters

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Proceedings Article | 22 February 2011 Paper

Broadband UV-Vis optical property measurement in layered turbid media

Quanzeng Wang, Du Le, Jessica Ramella-Roman, Joshua Pfefer

Proceedings Volume 7891, 78910F (2011) https://doi.org/10.1117/12.879647

KEYWORDS: Reflectivity, Tissues, Data modeling, Absorption, Fiber optics, Scattering, Optical fibers, Optical properties, Monte Carlo methods, Calibration

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Showing 5 of 21 publications

Course Instructor

NON-SPIE: ELECTRIC & MAGNETISM II

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NON-SPIE: Radiation Biology

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NON-SPIE: Medical Instrumentation: Application and Design

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NON-SPIE: Medical Instrumentation: Application and Design

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NON-SPIE: Medical Instrumentation: Application and Design

This is a course designed as an upper-level course which covers the basics of principles of medical instrumentation design. The course presents an insider's perspective on how medical instrumentation is designed, built, and functions. Since the cours

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NON-SPIE: Medical Instrumentation: Application and Design

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