Dr. Bin Deng Profile

Dr. Bin Deng

Instructor at Athinoula A Martinos Ctr for Biomedical Imaging

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Author

Publications (25)

SPIE Journal Paper | 11 May 2024 Open Access

Functional hemodynamic imaging markers for the prediction of pathological outcomes in breast cancer patients treated with neoadjuvant chemotherapy

Bin Deng, Ailis Muldoon, Jayne Cormier, Nathaniel Mercaldo, Elizabeth Niehoff, Natalie Moffett, Mansi A. Saksena, Steven Isakoff, Stefan Carp

JBO, Vol. 29, Issue 06, 066001, (May 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.6.066001

KEYWORDS: Tumors, Breast, Digital breast tomosynthesis, Biomedical optics, Mammography, Tissues, Hemodynamics, Chemotherapy, Breast cancer, Magnetic resonance imaging

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SignificanceAchieving pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT) is a significant predictor of increased likelihood of survival in breast cancer patients. Early prediction of pCR is of high clinical value as it could allow personalized adjustment of treatment regimens in non-responding patients for improved outcomes.AimWe aim to assess the association between hemoglobin-based functional imaging biomarkers derived from diffuse optical tomography (DOT) and the pathological outcome represented by pCR at different timepoints along the course of NACT.ApproachTwenty-two breast cancer patients undergoing NACT were enrolled in a multimodal DOT and X-ray digital breast tomosynthesis (DBT) imaging study in which their breasts were imaged at different compression levels. Logistic regressions were used to study the associations between DOT-derived imaging markers evaluated after the first and second cycles of chemotherapy, respectively, with pCR status determined after the conclusion of NACT at the time of surgery. Receiver operating characteristic curve analysis was also used to explore the predictive performance of selected DOT-derived markers.ResultsNormalized tumor HbT under half compression was significantly lower in the pCR group compared to the non-pCR group after two chemotherapy cycles (p=0.042). In addition, the change in normalized tumor StO2 upon reducing compression from full to half mammographic force was identified as another potential indicator of pCR at an earlier time point, i.e., after the first chemo cycle (p=0.038). Exploratory predictive assessments showed that AUCs using DOT-derived functional imaging markers as predictors reach as high as 0.75 and 0.71, respectively, after the first and second chemo cycle, compared to AUCs of 0.50 and 0.53 using changes in tumor size measured on DBT and MRI.ConclusionsThese findings suggest that breast DOT could be used to assist response assessment in women undergoing NACT, a critical but unmet clinical need, and potentially enable personalized adjustments of treatment regimens.

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Proceedings Article | 7 March 2023 Presentation

Early prediction of neoadjuvant chemotherapy outcome with longitudinal breast diffuse optical tomography

Bin Deng, Ailis Muldoon, Jayne Cormier, Mansi Saksena, Steven Isakoff, Stefan Carp

Proceedings Volume PC12376, PC123760J (2023) https://doi.org/10.1117/12.2650855

KEYWORDS: Tumors, Breast, Diffuse optical tomography, Tissues, Imaging systems, Digital breast tomosynthesis, X-rays, X-ray imaging, Tissue optics, Optical imaging

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SPIE Journal Paper | 17 February 2022 Open Access

Erratum: Improved accuracy of cerebral blood flow quantification in the presence of systemic physiology cross-talk using multi-layer Monte Carlo modeling

Melissa Wu, Suk-Tak Chan, Dibbyan Mazumder, Davide Tamborini, Kimberly Stephens, Bin Deng, Parya Farzam, Joyce Chu, Maria Angela Franceschini, Jason Qu, Stefan Carp

NPh, Vol. 9, Issue 01, 019801, (February 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.1.019801

KEYWORDS: Physiology, Monte Carlo methods, Cerebral blood flow, Neurophotonics, Biomedical optics, Radiology, Radio optics, Medicine

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Proceedings Article | 5 March 2021 Presentation

Multimodal optical assessment of breast tumor aggressiveness and progression in murine models

Bin Deng, Ailis Muldoon, Rahul Pal, Alana Ross, Pamela Pantazopoulos, Zdravka Medarova, Anand T. Kumar, Stefan Carp

Proceedings Volume 11634, 116340B (2021) https://doi.org/10.1117/12.2577699

KEYWORDS: Tumors, Breast, Near infrared spectroscopy, Breast cancer, Tumor growth modeling, Spectroscopy, Luminescence, Indocyanine green, Imaging spectroscopy, Fluorescence spectroscopy

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Proceedings Article | 5 March 2021 Presentation

Deep learning enabled high-speed image reconstruction for breast diffuse optical tomography

Bin Deng, Hanxue Gu, Stefan Carp

Proceedings Volume 11639, 116390B (2021) https://doi.org/10.1117/12.2577736

KEYWORDS: Image restoration, Diffuse optical tomography, Breast, Process modeling, Tumors, Reconstruction algorithms, Data modeling, Tissue optics, Spherical lenses, Optimization (mathematics)

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Proceedings Article | 5 March 2021 Presentation

Characterization of cerebral blood flow quantification with diffuse correlation spectroscopy in the presence of systemic physiology cross-talk during a hypercapnic challenge

Stefan Carp, Melissa Wu, Suk-Tak Chan, Dibbyan Mazumder, Davide Tamborini, Kimberly Stephens, Bin Deng, Parya Farzam, Yawei Chu, Jason Qu, Maria Franceschini

Proceedings Volume 11629, 116291E (2021) https://doi.org/10.1117/12.2579027

KEYWORDS: Cerebral blood flow, Spectroscopy, Physiology, Tissue optics, Carbon dioxide, Ultrasonography, Tissues, Skin, Optical testing, Monte Carlo methods

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SPIE Journal Paper | 1 January 2021 Open Access

Improved accuracy of cerebral blood flow quantification in the presence of systemic physiology cross-talk using multi-layer Monte Carlo modeling

Melissa Wu, Suk-Tak Chan, Dibbyan Mazumder, Davide Tamborini, Kimberly Stephens, Bin Deng, Parya Farzam, Joyce Yawei Chu, Maria Angela Franceschini, Jason Qu, Stefan Carp

NPh, Vol. 8, Issue 01, 015001, (January 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.1.015001

KEYWORDS: Monte Carlo methods, Modulation, Brain, Physiology, Cerebral blood flow, Skull, Scattering, Carbon monoxide, Blood circulation, Data modeling

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Proceedings Article | 7 March 2019 Presentation + Paper

A chemist’s view of inflammation in contusion injured spinal cord in a rat model: noninvasive, noncontact, in vivo Raman spectroscopy minutes to hours after injury

Seth Fillioe, Kyle Kelly Bishop, Sai Han Tun, Paul Dent, Bin Deng, Charles Peterson, Jerry Goodisman, Julie Hasenwinkel, J. Chaiken

Proceedings Volume 10863, 108630G (2019) https://doi.org/10.1117/12.2509082

KEYWORDS: Injuries, Raman spectroscopy, Spinal cord, Inflammation, In vivo imaging, Control systems, Blood, Tissues, Tissue optics, Chemistry

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Proceedings Article | 26 February 2019 Presentation + Paper

Direct noninvasive real-time observation of thermoregulation physiology: periodic fluctuations in hematocrit and vascular volume in the peripheral circulation

Seth Fillioe, Paul Dent, Bin Deng, Sri Narsipur, Charles Peterson, Jerry Goodisman, Richard Steinmann, James Mostrom, J. Chaiken

Proceedings Volume 10868, 1086803 (2019) https://doi.org/10.1117/12.2509125

KEYWORDS: Blood, Physiology, Skin, Capillaries, Tissues, Plasma, Calibration, Vital signs, Raman spectroscopy, Tissue optics

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Proceedings Article | 12 February 2018 Presentation + Paper

Simultaneous, noninvasive, in vivo, continuous monitoring of hematocrit, vascular volume, hemoglobin oxygen saturation, pulse rate and breathing rate in humans and other animal models using a single light source

Paul Dent, Sai Han Tun, Seth Fillioe, Bin Deng, Josh Satalin, Gary Nieman, Kailyn Wilcox, Quinn Searles, Sri Narsipur, Charles Peterson, Jerry Goodisman, James Mostrom, Richard Steinmann, J. Chaiken

Proceedings Volume 10484, 1048410 (2018) https://doi.org/10.1117/12.2290231

KEYWORDS: Plasma, Oxygen, Blood, Tissues, Absorption, Skin, Lung, In vivo imaging, Light sources, Tissue optics

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SPIE Journal Paper | 27 April 2017 Open Access

Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis

Bernhard Zimmermann, Bin Deng, Bhawana Singh, Mark Martino, Juliette Selb, Qianqian Fang, Amir Sajjadi, Jayne Cormier, Richard Moore, Daniel Kopans, David Boas, Mansi Saksena, Stefan Carp

JBO, Vol. 22, Issue 04, 046008, (April 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.4.046008

KEYWORDS: Digital breast tomosynthesis, Breast, Sensors, Optical fibers, Absorption, X-rays, Breast cancer, Mammography, Tumors, Imaging systems

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Proceedings Article | 27 April 2016 Paper

Noninvasive in vivo plasma volume and hematocrit in humans: observing long-term baseline behavior to establish homeostasis for intravascular volume and composition

Paul Dent, Bin Deng, Jerry Goodisman, Charles Peterson, Sriram Narsipur, J. Chaiken

Proceedings Volume 9887, 98871S (2016) https://doi.org/10.1117/12.2227981

KEYWORDS: Plasma, Blood, In vivo imaging, Tissues, Tissue optics, Light scattering, Diagnostics, Geometrical optics, Skin, Blood, Spectroscopy, Fluorescence spectroscopy, Raman spectroscopy, Photoplethysmography, Luminescence, Scattering, Blood pressure

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SPIE Journal Paper | 11 August 2015 Open Access

Characterizing breast lesions through robust multimodal data fusion using independent diffuse optical and x-ray breast imaging

Richard Moore, Daniel Kopans, David Boas, Bin Deng, Maxim Fradkin, Jean-Michel Rouet, Mats Lundqvist, Qianqian Fang

JBO, Vol. 20, Issue 08, 080502, (August 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.8.080502

KEYWORDS: Breast, Tumors, Mammography, Tissue optics, Tissues, X-ray optics, X-rays, X-ray imaging, Image registration, Digital breast tomosynthesis

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Proceedings Article | 27 February 2014 Paper

Continuous noninvasive in vivo monitoring of intravascular plasma volume and hematocrit changes during hemodialysis in humans: direct comparison with the CRIT-LINE

Bin Deng, Evan Kastner, Sriram Narsipur, Jerry Goodisman, J. Chaiken

Proceedings Volume 8935, 89351N (2014) https://doi.org/10.1117/12.2043989

KEYWORDS: Plasma, Blood, Skin, Raman spectroscopy, Near infrared, Tissue optics, Absorption, In vivo imaging, Tissues, Light scattering

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Proceedings Article | 27 February 2014 Paper

Continuous noninvasive in vivo monitoring of intravascular plasma volume and hematocrit changes in response to blood removal and fluid replacement in a rat model

Bin Deng, Evan Kastner, P. Dent, J. Goodisman, J. Chaiken

Proceedings Volume 8935, 893526 (2014) https://doi.org/10.1117/12.2043976

KEYWORDS: Blood, Plasma, Luminescence, Raman spectroscopy, Skin, Tissues, Light scattering, Scattering, Absorption, In vivo imaging

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Proceedings Article | 1 February 2012 Paper

Singlet oxygen induced advanced glycation end-product photobleaching of in vivo human fingertip autofluorescence

Bin Deng, Anabel Simental, Patrick Lutz, George Shaheen, Joseph Chaiken

Proceedings Volume 8219, 82190D (2012) https://doi.org/10.1117/12.914050

KEYWORDS: Oxygen, Near infrared, Luminescence, In vivo imaging, Absorption, Tissues, Raman spectroscopy, Sensors, Blood, Skin

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Proceedings Article | 1 February 2012 Paper

Analyzing near infrared scattering from human skin to monitor changes in hematocrit

Joseph Chaiken, Bin Deng, Jerry Goodisman, George Shaheen, R. Bussjager

Proceedings Volume 8219, 821908 (2012) https://doi.org/10.1117/12.914051

KEYWORDS: Blood, Plasma, Tissues, Skin, Tissue optics, Near infrared, Scattering, In vivo imaging, Calibration, Photoplethysmography

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SPIE Journal Paper | 1 September 2011 Open Access

Analyzing near-infrared scattering from human skin to monitor changes in hematocrit

Joseph Chaiken, Bin Deng, Jerry Goodisman, George Shaheen, Rebecca Bussjaeger

JBO, Vol. 16, Issue 09, 097005, (September 2011) https://doi.org/10.1117/12.10.1117/1.3625283

KEYWORDS: Blood, Scattering, Plasma, Skin, Tissue optics, Luminescence, Tissues, Biological research, Light scattering, Absorption

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SPIE Journal Paper | 1 February 2011 Open Access

Raman spectroscopic investigation of spinal cord injury in a rat model

Tarun Saxena, Bin Deng, Julie Hasenwinkel, Dennis Stelzner, Joseph Chaiken

JBO, Vol. 16, Issue 02, 027003, (February 2011) https://doi.org/10.1117/12.10.1117/1.3549700

KEYWORDS: Raman spectroscopy, Spinal cord, Injuries, Luminescence, Tissues, Spectroscopy, In vivo imaging, Control systems, Cell death, In vitro testing

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Proceedings Article | 26 February 2010 Paper

Near infrared Raman spectroscopic study of reactive gliosis and the glial scar in injured rat spinal cords

Tarun Saxena, Bin Deng, Eric Lewis-Clark, Kyle Hoellger, Dennis Stelzner, Julie Hasenwinkel, Joseph Chaiken

Proceedings Volume 7560, 75600I (2010) https://doi.org/10.1117/12.846897

KEYWORDS: Raman spectroscopy, Spinal cord, Luminescence, Injuries, Tissues, In vivo imaging, Blood, Near infrared, Spectroscopy, In vitro testing

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Proceedings Article | 12 February 2010 Paper

Direct noninvasive observation of near infrared photobleaching of autofluorescence in human volar side fingertips in vivo

Bin Deng, Colin Wright, Eric Lewis-Clark, G. Shaheen, Roman Geier, J. Chaiken

Proceedings Volume 7560, 75600P (2010) https://doi.org/10.1117/12.846900

KEYWORDS: Luminescence, Tissues, Near infrared, In vivo imaging, Blood, Skin, Raman spectroscopy, Tissue optics, Glucose, In vitro testing

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SPIE Journal Paper | 1 September 2009 Open Access

Simultaneous, noninvasive observation of elastic scattering, fluorescence and inelastic scattering as a monitor of blood flow and hematocrit in human fingertip capillary beds

Joseph Chaiken, Jerry Goodisman, Bin Deng, Rebecca Bussjaeger, George Shaheen

JBO, Vol. 14, Issue 05, 050505, (September 2009) https://doi.org/10.1117/12.10.1117/1.3233629

KEYWORDS: Scattering, Light scattering, Plasma, Luminescence, Capillaries, Tissue optics, Skin, Blood, Tissues, Raman spectroscopy

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Proceedings Article | 14 February 2007 Paper

Methodology of effective glucose-specific signal extraction in complicated sample

Wenliang Chen, Bin Deng, Rong Liu, Xiaoyu Gu, Kexin Xu

Proceedings Volume 6445, 64450L (2007) https://doi.org/10.1117/12.699496

KEYWORDS: Glucose, Absorption, Calibration, Signal detection, Blood, Absorbance, Statistical analysis, Interference (communication), Data processing, Molecules

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Proceedings Article | 27 February 2006 Paper

The feasibility investigation of non-invasive blood glucose sensing based on near-infrared spectroscopy

Xiaoyu Gu, Bin Deng, Lin An, Wenliang Chen, Kexin Xu

Proceedings Volume 6094, 60940J (2006) https://doi.org/10.1117/12.645386

KEYWORDS: Glucose, Blood, Skin, Near infrared spectroscopy, Calibration, Veins, Spectroscopy, Arteries, Blood vessels, Near infrared

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Proceedings Article | 29 May 2002 Paper

Displacement measurements in microregion with generalized digital speckle correlation method

Xide Li, Bing Deng, Huiji Shi

Proceedings Volume 4537, (2002) https://doi.org/10.1117/12.468866

KEYWORDS: Speckle, Speckle pattern, Ceramics, Optical flow, Digital imaging, Experimental mechanics, Microelectromechanical systems, 3D image processing, Computing systems, Digital recording

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Showing 5 of 25 publications

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