In-depth reconstruction of anisotropic elasticity in the cornea following collagen crosslinking with time-resolved OCT and AuT-OCE

Ivan (Vanya) Pelivanov; Agathe Marmin; Gabriel Regnault; Ruikang K. Wang; Matthew O'Donnell; Tueng T. Shen

doi:10.1117/12.2692412

13 March 2024 In-depth reconstruction of anisotropic elasticity in the cornea following collagen crosslinking with time-resolved OCT and AμT-OCE

Ivan (Vanya) Pelivanov, Agathe Marmin, Gabriel Regnault, Ruikang K. Wang, Matthew O'Donnell, Tueng T. Shen

Author Affiliations +

Proceedings Volume PC12844, Optical Elastography and Tissue Biomechanics XI; PC1284401 (2024) https://doi.org/10.1117/12.2692412
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Corneal collagen crosslinking (CXL) is a surgical procedure to treat corneal ectasia. Ultraviolet (UV) light and riboflavin are combined to modify corneal microstructure by forming additional chemical bounds between stromal collagen fibers. Because of limited in-depth penetration of riboflavin and UV-light attenuation, a demarcation between treated and untreated regions can be observed, suggesting a two-layer structure after treatment. Here, we present a method of elastic moduli reconstruction in both cornea layers using OCE-tracked guided waves and an analytical model of a 2-layer nearly incompressible transversely isotropic (NITI) medium. An example of reconstruction is demonstrated in an ex vivo human cornea.

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Ivan (Vanya) Pelivanov, Agathe Marmin, Gabriel Regnault, Ruikang K. Wang, Matthew O'Donnell, and Tueng T. Shen "In-depth reconstruction of anisotropic elasticity in the cornea following collagen crosslinking with time-resolved OCT and AμT-OCE", Proc. SPIE PC12844, Optical Elastography and Tissue Biomechanics XI, PC1284401 (13 March 2024); https://doi.org/10.1117/12.2692412

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