Peripheral edema, also known as leg swelling, is observed frequently because of various causes such as sitting or standing for a long time, inflammation, injury or diseases in venous circulation system, lymphatic system, kidney and heart. It is also a side effect of chemotherapy or hormonal therapy. But to our knowledge, there is no wearable optical monitor that can quantify changes in the tissue water content related to edema. We have conducted simulations on the minimal number of light source-detector pairs and the wavelengths of the sources that can measure changes in the water fraction in superficial tissues within a compact form factor wearable optical sensor using continuous wave near-infrared spectroscopy (CW NIRS). The wavelength range we have investigated is from 800 to 1100 nm. We will present the results of simulations under various device configurations.
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