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Biological studies are increasingly using optical forces to study cellular behavior and intracellular interactions. In this talk, we discuss the use of optically generated forces in biomedical treatment and diagnostics with specific reference to traumatic brain injury (TBI). Our biophotonic workstation includes optical tweezers, quantitative phase microscopy, fluorescence imaging, and laser-induced shockwaves to study cellular damage. We discuss our studies on astrocyte damage repair mechanisms as well as how the optical toolbox enables the study of intracellular signaling and cellular dynamics and anatomy.
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Daryl C. Preece, Pegah Pouladian, Nicole Wakida, Veronica Gomez, "Applications of optically generated forces to study cellular interactions and signaling," Proc. SPIE PC12663, Molecular and Nanophotonic Machines VI, PC126630C (5 October 2023); https://doi.org/10.1117/12.2677977