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16 March 2023 High-resolution brain imaging via a multimode fiber (Conference Presentation)
Benjamin Lochocki, Max V. Verweg, Jeroen J. M. Hoozemans, Johannes F. de Boer, Lyubov V. Amitonova
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Proceedings Volume PC12388, Adaptive Optics and Wavefront Control for Biological Systems IX; PC123880D (2023) https://doi.org/10.1117/12.2648922
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
The use of a single multimode fiber (MMF) as a high-resolution endoscopic imaging tool is demonstrated. We show that the scrambled output of a MMF can be used for auto-fluorescence compressive imaging. By scanning a light spot across the proximal side of the fiber we can create uncorrelated speckle patterns at the output. Those patterns successively illuminate the biological sample and for each pattern the integrated intensity is recorded in epi-direction. An image of the brain tissue was computationally reconstructed using a regularization algorithm. Furthermore, the presented technique has potential in enhanced acquisition speed and in improving the resolution limit.
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Benjamin Lochocki, Max V. Verweg, Jeroen J. M. Hoozemans, Johannes F. de Boer, and Lyubov V. Amitonova "High-resolution brain imaging via a multimode fiber (Conference Presentation)", Proc. SPIE PC12388, Adaptive Optics and Wavefront Control for Biological Systems IX, PC123880D (16 March 2023); https://doi.org/10.1117/12.2648922
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KEYWORDS
Brain imaging
Multimode fibers
Speckle pattern
Raster graphics
Microscopy
Neuroimaging
Reconstruction algorithms
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