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9 March 2023 Photoacoustic oxygen imaging for prediction of radiation therapy efficacy
Janggun Jo, Jeff Folz, Raoul Kopelman, Celina Kleer, Xueding Wang
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Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC123790N (2023) https://doi.org/10.1117/12.2649303
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Presented here is an application of the new approach of chemical imaging, performing an in-vivo chemical analysis, to predict a given tumor’s response to radiation therapy. Cancer tumors’ oxygen distributions in PDX mice was imaged by photoacoustic imaging with tumor-targeted oxygen sensor nanoparticles. Following radiation therapy, we established a quantitatively significant correlation between the spatial distribution of the initial oxygen levels and the spatial distribution of the therapy’s efficacy: the higher the local oxygen, the higher the local radiation therapy efficacy. The presented cancer chemical imaging provides a non-invasive method to predict the efficacy of radiotherapy for a given tumor.
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Janggun Jo, Jeff Folz, Raoul Kopelman, Celina Kleer, and Xueding Wang "Photoacoustic oxygen imaging for prediction of radiation therapy efficacy", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123790N (9 March 2023); https://doi.org/10.1117/12.2649303
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KEYWORDS
Oxygen
Radiotherapy
Tumors
Photoacoustic spectroscopy
Photoacoustic imaging
Imaging spectroscopy
Chemical analysis
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