Characterization of picosecond laser modules for time-domain diffuse correlation spectroscopy application

Saeed Samaei; Lorenzo Colombo; Dawid Borycki; Marco Pagliazzi; Turgut Durduran; Piotr Sawosz; Stanislaw Wojtkiewicz; Davide Contini; Alessandro Torricelli; Antonio Pifferi; Adam Liebert

doi:10.1117/12.2609557

2 March 2022 Characterization of picosecond laser modules for time-domain diffuse correlation spectroscopy application

Saeed Samaei, Lorenzo Colombo, Dawid Borycki, Marco Pagliazzi, Turgut Durduran, Piotr Sawosz, Stanislaw Wojtkiewicz, Davide Contini, Alessandro Torricelli, Antonio Pifferi, Adam Liebert

Author Affiliations +

Proceedings Volume PC11959, Dynamics and Fluctuations in Biomedical Photonics XIX; PC119590B (2022) https://doi.org/10.1117/12.2609557
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Time-domain diffuse correlation spectroscopy (TD-DCS) is a non-invasive optical technique, which measures tissue blood flow with path-length resolution. Ideally, this technique requires a pulsed laser with an adequate illumination power, a long coherence length, and a narrow instrument response function (IRF), while available laser modules cannot satisfy all these conditions. We systematically characterized three pulsed laser sources and compared their performances using phantom and in vivo measurements. We found that each laser has the potential to be used in TD-DCS applications. Also, the effects caused by the IRF are more significant than the effect of the limited coherence length.

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Saeed Samaei, Lorenzo Colombo, Dawid Borycki, Marco Pagliazzi, Turgut Durduran, Piotr Sawosz, Stanislaw Wojtkiewicz, Davide Contini, Alessandro Torricelli, Antonio Pifferi, and Adam Liebert "Characterization of picosecond laser modules for time-domain diffuse correlation spectroscopy application", Proc. SPIE PC11959, Dynamics and Fluctuations in Biomedical Photonics XIX, PC119590B (2 March 2022); https://doi.org/10.1117/12.2609557

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