Silvia Noble Anbunesan,1 Alba Alfonso García,1 Xiangnan Zhou,1 Julien Bechttps://orcid.org/0000-0003-1222-4071,1 Roberto Frusciante,1 Lisanne Kraft,1 Brent Weyers,1 Matthew Bobinski,1 Han Sung Lee,1 Lee-Way Jin,1 Orin Bloch,1 Laura Marcu1
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The standard treatment for infiltrative gliomas is surgery to remove as much tumor tissue as possible without compromising neurological functions. Thus, real-time identification of infiltrative tumor tissue is necessary. Here a fluorescence lifetime imaging (FLIm) was used to distinguish between healthy brain and areas with different degrees of tumor cellularity as defined by histopathology. We conducted FLIm measurements and collected microbiopsies from tumor resection margins to identify the FLIm characteristics of tumor edges in cortex and white matter of low- and high-grade gliomas. Results from a 13-patient cohort indicate that FLIm identifies infiltrations of up to moderate tumor cellularity.
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Silvia Noble Anbunesan, Alba Alfonso García, Xiangnan Zhou, Julien Bec, Roberto Frusciante, Lisanne Kraft, Brent Weyers, Matthew Bobinski, Han Sung Lee, Lee-Way Jin, Orin Bloch, Laura Marcu, "Real-time interrogation of brain tumors using intraoperative FLIm," Proc. SPIE PC11949, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XX, PC1194904 (9 March 2022); https://doi.org/10.1117/12.2610424