New biomarkers derived from hybrid diffuse optical techniques: a first step to personalized treatment in the stroke unit

Lisa Kobayashi Frisk; Jonas B. Fischer; Anna Bosch de Basea Gomez; Marta Navarro Roman; Izaskun Belmonte Jimeno; Manel Pérez Marín; Anabel Alba Pérez; Clara Gregori-Pla; Udo M. Weigel; Daniel Guisado Alonso; Joan Martí-Fàbregas; Raquel Delgado-Mederos; Turgut Durduran

doi:10.1117/12.2610183

7 March 2022 New biomarkers derived from hybrid diffuse optical techniques: a first step to personalized treatment in the stroke unit

Lisa Kobayashi Frisk, Jonas B. Fischer, Anna Bosch de Basea Gomez, Marta Navarro Roman, Izaskun Belmonte Jimeno, Manel Pérez Marín, Anabel Alba Pérez, Clara Gregori-Pla, Udo M. Weigel, Daniel Guisado Alonso, Joan Martí-Fàbregas, Raquel Delgado-Mederos, Turgut Durduran

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Proceedings Volume PC11945, Clinical and Translational Neurophotonics 2022; PC1194509 (2022) https://doi.org/10.1117/12.2610183
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

A limiting factor for personalizing therapies in stroke patients is the inability to continuously monitor the cerebral status of patients. In particular, potential impairment of cerebral autoregulation (CA) in these patients may incur certain risks during their mobilization. We have used hybrid diffuse optical techniques to measure new biomarkers related to CA status as well as metabolic health in a large cohort of stroke patients in order to determine biomarkers indicative of clinical improvement. If validated, these results can pave the way towards personalization of stroke therapy based on direct measures of cerebral health.

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Lisa Kobayashi Frisk, Jonas B. Fischer, Anna Bosch de Basea Gomez, Marta Navarro Roman, Izaskun Belmonte Jimeno, Manel Pérez Marín, Anabel Alba Pérez, Clara Gregori-Pla, Udo M. Weigel, Daniel Guisado Alonso, Joan Martí-Fàbregas, Raquel Delgado-Mederos, and Turgut Durduran "New biomarkers derived from hybrid diffuse optical techniques: a first step to personalized treatment in the stroke unit", Proc. SPIE PC11945, Clinical and Translational Neurophotonics 2022, PC1194509 (7 March 2022); https://doi.org/10.1117/12.2610183

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KEYWORDS

Hybrid optics

Diffuse optical imaging

Near infrared spectroscopy

Biological research

Cerebral blood flow

Oxygen

Receivers

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