Fluorophore-conjugated antibodies for imaging and resection of GI tumors

Michael Bouvet; Robert M. Hoffman

doi:10.1117/12.2208811

4 March 2016 Fluorophore-conjugated antibodies for imaging and resection of GI tumors

Michael Bouvet, Robert M. Hoffman

Proceedings Volume 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II; 96960O (2016) https://doi.org/10.1117/12.2208811
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Negative surgical margins are critical to prevent recurrence in cancer surgery. This is because with current technology in many cases negative margins are impossible due the inability of the surgeon to detect the margin. Our laboratory has developed fluorophore-labeled monoclonal antibodies to aid in cancer visualization in orthotopic nude mouse models of human gastrointestinal (GI) cancer in order to achieve negative margins in fluorescence-guided surgery (FGS). The technologies described herein have the potential to change the paradigm of surgical oncology to engender significantly improved outcomes.

Conference Presentation

Citation Download Citation

Michael Bouvet and Robert M. Hoffman "Fluorophore-conjugated antibodies for imaging and resection of GI tumors", Proc. SPIE 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II, 96960O (4 March 2016); https://doi.org/10.1117/12.2208811

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available