Transcutaneous monitoring of steroid-induced osteoporosis with Raman spectroscopy

Jason R. Maher; Jason Inzana; Masahiko Takahata; Hani A. Awad; Andrew J. Berger

doi:10.1117/12.908361

31 January 2012 Transcutaneous monitoring of steroid-induced osteoporosis with Raman spectroscopy

Jason R. Maher, Jason Inzana, Masahiko Takahata, Hani A. Awad, Andrew J. Berger

Proceedings Volume 8219, Biomedical Vibrational Spectroscopy V: Advances in Research and Industry; 82190P (2012) https://doi.org/10.1117/12.908361
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Although glucocorticoids are among the most frequently prescribed anti-inflammatory agents used in the treatment of rheumatoid arthritis, extended exposure to this steroid hormone is the leading cause of iatrogenic osteoporosis. Recently, Raman spectroscopy has been utilized to exploit biochemical differences between osteoporotic and normal bones in order to predict fracture risk. In this presentation, we report the results of ongoing research in our laboratory towards the clinical translation of this technique. We will discuss strategies for the transcutaneous acquisition of spectra from the tibiae of mice that are of sufficient quality to generate accurate predictions of fracture risk.

Citation Download Citation

Jason R. Maher, Jason Inzana, Masahiko Takahata, Hani A. Awad, and Andrew J. Berger "Transcutaneous monitoring of steroid-induced osteoporosis with Raman spectroscopy", Proc. SPIE 8219, Biomedical Vibrational Spectroscopy V: Advances in Research and Industry, 82190P (31 January 2012); https://doi.org/10.1117/12.908361

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