Optical coherence tomography reveals in vivo cortical structures of adult rats in response to cerebral ischemia injury

Yi-rong Ni; Zhou-yi Guo; So-yun Shu; Xin-min Bao

doi:10.1117/12.821579

6 March 2009 Optical coherence tomography reveals in vivo cortical structures of adult rats in response to cerebral ischemia injury

Yi-rong Ni, Zhou-yi Guo, So-yun Shu, Xin-min Bao

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Proceedings Volume 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine; 72801M (2009) https://doi.org/10.1117/12.821579
Event: Photonics and Optoelectronics Meetings, 2008, Wuhan, China

Abstract

Optical coherence tomography(OCT) is a high resolution imaging technique which uses light to directly image living tissue. we investigate the potential use of OCT for structural imaging of the ischemia injury mammalian cerebral cortex. And we examine models of middle cerebral artery occlusion (MCAO) in rats in vivo using OCT. In particular, we show that OCT can perform in vivo detection of cortex and differentiate normal and abnormal cortical anatomy. This OCT system in this study provided an axial resolution of 10~15μ m, the transverse resolution of the system is about 25 μm. OCT can provide cross-sectional images of cortical of adult rats in response to cerebral ischemia injury.We conclude that OCT represents an exciting new approach to visualize, in real-time, pathological changes in the cerebral cortex structures and may offer a new tool for Possible neuroscience clinical applications.

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Yi-rong Ni, Zhou-yi Guo, So-yun Shu, and Xin-min Bao "Optical coherence tomography reveals in vivo cortical structures of adult rats in response to cerebral ischemia injury", Proc. SPIE 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine, 72801M (6 March 2009); https://doi.org/10.1117/12.821579

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KEYWORDS

Optical coherence tomography

Ischemia

Cerebral cortex

In vivo imaging

Arteries

Brain

Injuries

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