An improved algorithm of fiber tractography demonstrates postischemic cerebral reorganization

Xiao-dong Liu; Jie Lu; Li Yao; Kun-cheng Li; Xiao-jie Zhao

doi:10.1117/12.770175

12 March 2008 An improved algorithm of fiber tractography demonstrates postischemic cerebral reorganization

Xiao-dong Liu, Jie Lu, Li Yao, Kun-cheng Li, Xiao-jie Zhao

Proceedings Volume 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images; 69161T (2008) https://doi.org/10.1117/12.770175
Event: Medical Imaging, 2008, San Diego, California, United States

Abstract

In vivo white matter tractography by diffusion tensor imaging (DTI) accurately represents the organizational architecture of white matter in the vicinity of brain lesions and especially ischemic brain. In this study, we suggested an improved fiber tracking algorithm based on TEND, called TENDAS, for tensor deflection with adaptive stepping, which had been introduced a stepping framework for interpreting the algorithm behavior as a function of the tensor shape (linear-shaped or not) and tract history. The propagation direction at each step was given by the deflection vector. TENDAS tractography was used to examine a 17-year-old recovery patient with congenital right hemisphere artery stenosis combining with fMRI. Meaningless picture location was used as spatial working memory task in this study. We detected the shifted functional localization to the contralateral homotypic cortex and more prominent and extensive left-sided parietal and medial frontal cortical activations which were used directly as seed mask for tractography for the reconstruction of individual spatial parietal pathways. Comparing with the TEND algorithms, TENDAS shows smoother and less sharp bending characterization of white matter architecture of the parietal cortex. The results of this preliminary study were twofold. First, TENDAS may provide more adaptability and accuracy in reconstructing certain anatomical features, whereas it is very difficult to verify tractography maps of white matter connectivity in the living human brain. Second, our study indicates that combination of TENDAS and fMRI provide a unique image of functional cortical reorganization and structural modifications of postischemic spatial working memory.

Citation Download Citation

Xiao-dong Liu, Jie Lu, Li Yao, Kun-cheng Li, and Xiao-jie Zhao "An improved algorithm of fiber tractography demonstrates postischemic cerebral reorganization", Proc. SPIE 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images, 69161T (12 March 2008); https://doi.org/10.1117/12.770175

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KEYWORDS

Diffusion tensor imaging

Functional magnetic resonance imaging

Brain

Detection and tracking algorithms

Diffusion

Brain mapping

Neuroimaging

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