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28 February 2006 Effects of low intensity laser irradiation during healing of infected skin lesions in the rat
Ethne L. Nussbaum, Lothar Lilge, Tony Mazzulli, Kenneth P.H. Pritzker
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Proceedings Volume 6140, Mechanisms for Low-Light Therapy; 61400L (2006) https://doi.org/10.1117/12.647166
Event: SPIE BiOS, 2006, San Jose, California, United States
Abstract
Purpose: To determine the effect of low intensity laser therapy (LILT) on healing of infected skin wounds in the rat. Methods: Wounds on the dorsum of Sprague-Dawley rats (14 per group) were inoculated or sham-inoculated with P. aeruginosa. Wounds were irradiated or sham-irradiated three times weekly from Day 1-19 using 635nm or 808nm diode lasers at radiant exposure of 1 or 20 J/cm2 delivered in continuous wave (CW) or at an intensity modulation frequency of 3800Hz. Wound area and bacterial growth were evaluated three times weekly. Results: CW 808 nm (1 and 20 J/cm2) irradiation generally delayed healing in acute wounds. However, from Day 10 onwards CW 808 nm (1 J/cm2 and 20 J/cm2) and 808 nm 3800 Hz (1 J/cm2) irradiation improved healing in inoculated wounds. Healing in acute wounds improved using 635 nm irradiation at low radiant exposure (1 J/cm2); however, using 635 nm irradiation at high radiant exposure (20 J/cm2) delayed healing. Bacterial balance in wounds was significantly altered using 635 nm (20 J/cm2) and CW 808 nm irradiation (1 and 20 J/cm2). Conclusion: Clearing wounds of normal flora was not associated with improved healing. Proliferation of staphylococcal species in wounds was associated with delayed healing.
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Ethne L. Nussbaum, Lothar Lilge, Tony Mazzulli, and Kenneth P.H. Pritzker "Effects of low intensity laser irradiation during healing of infected skin lesions in the rat", Proc. SPIE 6140, Mechanisms for Low-Light Therapy, 61400L (28 February 2006); https://doi.org/10.1117/12.647166
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KEYWORDS
Wound healing
Low-intensity laser therapy
Skin
Bacteria
Tissues
Continuous wave operation
Laser irradiation
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